3-(4-Fluorophenyl)-2,2-diMethylpropanoic acid

Base Information

Chemical Name:3-(4-Fluorophenyl)-2,2-diMethylpropanoic acid
CAS No.:676621-96-8
Molecular Formula:C11H13FO2
Molecular Weight:196.2181232
Hs Code.:
Mol file:676621-96-8.mol

Synonyms:3-(4-Fluorophenyl)-2,2-diMethylpropanoic acid;4-Fluoro-a,a-dimethylbenzenepropanoic acid

Suppliers and Price of 3-(4-Fluorophenyl)-2,2-diMethylpropanoic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Crysdot
3-(4-Fluorophenyl)-2,2-dimethylpropanoicacid 95+%
5g
$ 700.00

Chemenu
3-(4-Fluorophenyl)-2,2-dimethylpropanoicacid 95%
5g
$ 661.00

American Custom Chemicals Corporation
3-(4-FLUOROPHENYL)-2,2-DIMETHYLPROPANOIC ACID 95.00%
5MG
$ 497.43

Alichem
3-(4-Fluorophenyl)-2,2-dimethylpropanoicacid
5g
$ 552.90

Acrotein
4-Fluoro-a,a-dimethylbenzenepropanoicacid 97%
1g
$ 302.50

Total 9 raw suppliers

Chemical Property of 3-(4-Fluorophenyl)-2,2-diMethylpropanoic acid

Chemical Property:

Boiling Point:293.7±15.0 °C(Predicted)
PKA:4.72±0.13(Predicted)
PSA：37.30000
Density:1.149±0.06 g/cm3(Predicted)
LogP:2.47900
Storage Temp.:2-8°C

Purity/Quality:

97% ^*data from raw suppliers

3-(4-Fluorophenyl)-2,2-dimethylpropanoicacid 95+% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Uses 3-(4-Fluorophenyl)-2,2-dimethylpropanoic acid is used as a reactant in the preparation of β-arylation of carboxamides via iron-catalyzed C(sp3)-H bond activation.

Technology Process of 3-(4-Fluorophenyl)-2,2-diMethylpropanoic acid

There total 5 articles about 3-(4-Fluorophenyl)-2,2-diMethylpropanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 547-63-7,133320-07-7,67505-84-4
Methyl isobutyrate

: 459-46-1
4-Fluorobenzyl bromide

: 676621-96-8
3-(4-Fluorophenyl)-2,2-dimethyl-propionic Acid

Guidance literature:: Methyl isobutyrate; With n-butyllithium; diisopropylamine; In tetrahydrofuran; hexane; for 0.5h; Inert atmosphere;

4-Fluorobenzyl bromide; In tetrahydrofuran; hexane; for 20.1667h; Inert atmosphere;

With sodium hydroxide; In methanol; water; at 80 ℃; for 24h; Inert atmosphere;
DOI:10.1021/acs.joc.7b01202

Reference yield: 87.0%

: 676621-95-7
3-(4-Fluorophenyl)-2,2-dimethyl-propionic Acid Ethyl Ester

: 676621-96-8
3-(4-Fluorophenyl)-2,2-dimethyl-propionic Acid

Guidance literature:: 3-(4-Fluorophenyl)-2,2-dimethyl-propionic Acid Ethyl Ester; With sodium hydroxide; water; for 18h; Heating / reflux;

With hydrogenchloride; In water; at 0 ℃; pH=1;