4-Fluoro-1-O,2-O,3-O,6-O-tetraacetyl-4-deoxy-β-D-glucopyranose

Base Information

Chemical Name:4-Fluoro-1-O,2-O,3-O,6-O-tetraacetyl-4-deoxy-β-D-glucopyranose
CAS No.:27108-07-2
Molecular Formula:C14H19FO9
Molecular Weight:350.29
Hs Code.:
Mol file:27108-07-2.mol

Synonyms:4-Fluoro-1-O,2-O,3-O,6-O-tetraacetyl-4-deoxy-β-D-glucopyranose

Suppliers and Price of 4-Fluoro-1-O,2-O,3-O,6-O-tetraacetyl-4-deoxy-β-D-glucopyranose

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Chemicals and raw materials
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Total 3 raw suppliers

Chemical Property of 4-Fluoro-1-O,2-O,3-O,6-O-tetraacetyl-4-deoxy-β-D-glucopyranose

Chemical Property:

PSA：114.43000
LogP:0.03900

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

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Technology Process of 4-Fluoro-1-O,2-O,3-O,6-O-tetraacetyl-4-deoxy-β-D-glucopyranose

There total 6 articles about 4-Fluoro-1-O,2-O,3-O,6-O-tetraacetyl-4-deoxy-β-D-glucopyranose which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

: 30694-44-1
(3R,4R,5S,6R)-5-fluoro-6-(hydroxymethyl)tetrahydro-2H-pyran-2,3,4-triol

: 108-24-7
acetic anhydride

: 27108-07-2
(2S,3R,4R,5R,6R)-6-(acetoxymethyl)-5-fluorotetrahydro-2H-pyran-2,3,4-triyl triacetate

Guidance literature:: With pyridine; for 48h; Ambient temperature;
DOI:10.1016/S0008-6215(00)90028-4

Reference yield:

: 3601-36-3,6344-46-3
methyl 2,3,6-tri-O-benzoyl-α-D-galactopyranoside

: 27108-07-2
(2S,3R,4R,5R,6R)-6-(acetoxymethyl)-5-fluorotetrahydro-2H-pyran-2,3,4-triyl triacetate

Guidance literature:: Multi-step reaction with 4 steps

1: 50.5 percent / DAST / CH₂Cl₂

2: 65.9 percent / NaOMe / methanol

3: aq. HCl

4: 44.4 percent / NaOAc / 1.) reflux, 50 min, 2.) r.t., 2 h

With hydrogenchloride; sodium methylate; sodium acetate; 4,4'-diaminostilbene-2,2'-disulfonic acid; In methanol; dichloromethane;
DOI:10.1021/jo00102a024

Reference yield:

: 84065-98-5
Methyl 2,3,6-Tri-O-benzoyl-4-deoxy-4-fluoro-α-D-glucopyranoside

: 27108-07-2
(2S,3R,4R,5R,6R)-6-(acetoxymethyl)-5-fluorotetrahydro-2H-pyran-2,3,4-triyl triacetate

Guidance literature:: Multi-step reaction with 3 steps

1: 65.9 percent / NaOMe / methanol

2: aq. HCl

3: 44.4 percent / NaOAc / 1.) reflux, 50 min, 2.) r.t., 2 h

With hydrogenchloride; sodium methylate; sodium acetate; In methanol;
DOI:10.1021/jo00102a024