84065-98-5

Usage

Uses

Used in Organic Synthesis:
α-D-galactopyranoside,methy-4-deoxy-4-fluoro-,tribenzoate is used as a synthetic intermediate in the preparation of various organic compounds. Its unique structure allows for the formation of new chemical entities with potential applications in pharmaceuticals, agrochemicals, and other industries.
Used in Pharmaceutical Industry:
α-D-galactopyranoside,methy-4-deoxy-4-fluoro-,tribenzoate is used as a building block for the development of novel pharmaceutical compounds. Its unique structure can be utilized to design and synthesize new drugs with improved therapeutic properties, such as enhanced bioavailability, selectivity, and reduced side effects.
Used in Agrochemical Industry:
α-D-galactopyranoside,methy-4-deoxy-4-fluoro-,tribenzoate is used as a key intermediate in the synthesis of agrochemicals, such as pesticides and herbicides. Its unique structure can contribute to the development of more effective and environmentally friendly agrochemicals.
Used in Research and Development:
α-D-galactopyranoside,methy-4-deoxy-4-fluoro-,tribenzoate is used as a research tool in various scientific studies. Its unique structure can provide insights into the synthesis, properties, and applications of other complex organic compounds, contributing to the advancement of scientific knowledge in the field of organic chemistry.

Upstream product

• 3601-36-3 methyl 2,3,6-tri-O-benzoyl-α-D-galactopyranoside 
• 98-88-4 benzoyl chloride 

Downstream Products

• 27108-07-2 (2S,3R,4R,5R,6R)-6-(acetoxymethyl)-5-fluorotetrahydro-2H-pyran-2,3,4-triyl triacetate 
• 30694-44-1 (3R,4R,5S,6R)-5-fluoro-6-(hydroxymethyl)tetrahydro-2H-pyran-2,3,4-triol 
• 1228019-05-3 C₂₇H₂₃FO₈ 
• 62182-11-0 3-fluoro-3-deoxy-α-D-glucose 
• 56926-53-5 Methyl 4-Deoxy-4-fluoro-α-D-glucopyranoside 
• 702638-17-3 1-O-acetyl 2,3,6-tri-O-benzoyl-4-fluoro-4-deoxy-glucose 
• 701936-21-2 4-deoxy-4-fluoro-1-O-acetyl-2,3,6-tri-O-benzoyl-D-glucopyranose 

Relevant academic research and scientific papers

Preparation of Nonradioactive Standards and a Precursor for a Hypoxia 18 F PET Tracer Derived from 1-(β- d -Galactopyranosyl)-2-nitroimidazole

Acetyl-protected 1-(β- d -galactopyranosyl)-2-nitroimidazole was converted to a potential precursor for a fluorine-18 labeled hypoxia tumor marker. Two nonradioactive standards, the 6′-deoxy-6′-fluorogalactosyl and the 4′-deoxy-4′-fluoroglucosyl analogue

Process development of selectively benzoylated and fluorinated glycosyl donors

Route selection, process development and large-scale preparation of selectively benzoylated and fluorinated d-glucopyranoses, required as glycosyl donors for the synthesis of the SGLT inhibitor SAR7226, are discussed.

METHOD FOR PRODUCING 4-DEOXY-4-FLUORO-D-GLUCOSE DERIVATIVE

There is disclosed a method for producing a 4-deoxy-4-fluoro-D-glucose derivative by reacting a D-galactose derivative with either sulfuryl fluoride (SO2F2), trifluoromethanesulfonyl fluoride (CF3SO2F) or perflu

Synthesis and structure elucidation of benzoylated deoxyfluoropyranosides

Benzoylated deoxyfluoropyranosides have been synthesized, starting with protected, unprotected, or fluorinated precursors. Fluorination of eight derivatives was compared using DAST and Deoxo-Fluor as reagents. Deoxo-Fluor was found to be especially useful

Novel aromatic fluoroglycoside derivatives, medicaments containing these compounds, and the use thereof

Novel aromatic fluoroglycoside derivatives, medicaments containing these compounds, and the use thereof. The invention relates to substituted aromatic fluoroglycoside derivatives of the formula I in which the radicals have the stated meanings, and their p

NOVEL FLUOROGLYCOSIDE DERIVATIVES OF PYRAZOLES, MEDICAMENTS CONTAINING THESE COMPOUNDS, AND THE USE THEREOF

The invention relates to substituted fluoroglycoside derivatives of pyrazoles of formula (I), in which the radicals have the indicated meanings, to the physiologically compatible salts thereof, and to a method for the production thereof. The compounds are suited for as, e.g. antidiabetics.

NOVEL FLUOROGLYCOSIDE HETEROCYCLIC DERIVATIVES, PHARMACEUTICAL PRODUCTS CONTAINING SAID COMPOUNDS AND THE USE THEREOF

The invention relates to substituted fluoroglycoside heterocyclic derivatives of a formula (I), wherein radicals have predefined bonds, to the psychologically tolerated salts thereof and to methods for the preparation thereof. Said compounds can be used, for example as antidiabetic agents.

Synthesis of UDP-4-deoxy-4-fluoroglucose and UDP-4-deoxy-4-fluorogalactose and their interactions with enzymes of nucleotide sugar metabolism

Fluorinated carbohydrates can be used as probes of enzymatic active sites. We report the synthesis of 4-deoxy-4-fluoro-α-D-galactose-1-phosphate and the substrate analogues of UDP-galactose, UDP4-deoxy-4-fluoro-α-D-galactose (UDP-FGal), and of UDP-glucose, UDP-4-deoxy-4-fluoro-α-D-glucose (UDP-FGlc), which may be useful in analyzing the binding properties of enzymes that utilize nucleotide sugars as substrates. As a first step in this study, we determine the kinetic and inhibition parameters for UDP-FGal and UDP-FGlc interacting with UDP-glucose dehydrogenase and UDP-galactose 4-epimerase. UDP-FGlc is a substrate for bovine liver UDP-glucose dehydrogenase: K(m) = 30.2 ± 4.5 μM slightly higher than the value 9.6 ± 0.7 μM for UDP-glucose, and V(m)(UDP-FGlc) = 0.46V(mUDP-Glc). UDP-FGal is not a substrate for UDP-glucose dehydrogenase but is a competitive inhibitor with respect to UDP-glucose (K(i) = 19.9 ± 6.6 μM). These analogs also bind to UDP-galactose 4-epimerase from E. coli with dissociation constants K(d) of 1.4 and 1.1 mM for UDP-FGlc and UDP-FGal, respectively.

THE SYNTHESIS AND HYDROLYSIS OF A SERIES OF DEOXYFLUORO-D-GLUCOPYRANOSYL PHOSPHATES

The synthesis of all four deoxyfluoro-α-D-glucopyranosyl phosphates is described.Rate conctants for their acid-catalyzed hydrolysis were determined, and fluorine substitution was shown to have a significant effect in lowering the rate, particularly when t