6,7-Dimethyllumazine

Base Information

• Chemical Name: 6,7-Dimethyllumazine
• CAS No.: 5774-32-3
• Molecular Formula: C8H8N4O2
• Molecular Weight: 192.1747
• NSC Number: 45780
• DSSTox Substance ID: DTXSID50418035
• Nikkaji Number: J103.948B
• Mol file: 5774-32-3.mol

Synonyms:6,7-dimethyllumazine

Chemical Property of 6,7-Dimethyllumazine

Chemical Property:

• Boiling Point: °Cat760mmHg
• Flash Point: °C
• PSA: 91.50000
• Density: 1.369g/cm³
• LogP: -0.37680
• XLogP3: -0.2
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 0
• Exact Mass: 192.06472551
• Heavy Atom Count: 14
• Complexity: 281

Purity/Quality:

98%min ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=C(N=C2C(=N1)C(=O)NC(=O)N2)C

Technology Process of 6,7-Dimethyllumazine

There total 16 articles about 6,7-Dimethyllumazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

2-(benzylsulfanyl)-6,7-dimethyl-4(3H)-pteridinone (606964-89-0) → 6,7-dimethyllumazine (5774-32-3)

Guidance literature:

With potassium peroxomonosulfate; In methanol; at 20 ℃; for 4h;

DOI:10.1039/b300798g

Reference yield: 79.0%

4,5-diaminouracil-hydrochloride + dimethylglyoxal (431-03-8) → 6,7-dimethyllumazine (5774-32-3)

Guidance literature:

With hydrogenchloride; In ethanol; water;

Reference yield: 45.0%

C4H6N4O2*0.5H2O4S + dimethylglyoxal (431-03-8) → 6,7-dimethyllumazine (5774-32-3)

Guidance literature:

In water; at 100 ℃; for 0.25h;

DOI:10.1039/b816876h

upstream raw materials:

5,6-diaminouracil

dimethylglyoxal

6,7-dimethyl-2,4-pteridine-2,4-diamine

2,4-dichloro-6,7-dimethylpteridine

Downstream raw materials:

3-amino-5,6-dimethyl-pyrazine-2-carboxylic acid

2-amino-5,6-dimethylpyrazine

sulfanilic acid-(5,6-dimethyl-pyrazin-2-ylamide)

1-(2,3-dideoxy-3-iodo-5-O-p-toluoyl-β-D-erythro-pentofuranosyl)-6,7-dimethyllumazine

Refernces

• 1、 Ye, Zhiqiang,Rajendar, Burki,Qing, Dai,Nishizawa, Seiichi,Teramae, Norio. "6,7-Dimethyllumazine as a potential ligand for selective recognition of adenine opposite an abasic site in DNA duplexes". . p. 6588 - 6590. Retrieved 2008.
• 2、 Gibson, Colin L.,La Rosa, Salvatore,Suckling, Colin J.. "A prototype solid phase synthesis of pteridines and related heterocyclic compounds". . p. 1909 - 1918. Retrieved 2007/10/03.