Volitinib

Base Information

Chemical Name:Volitinib
CAS No.:1313725-88-0
Molecular Formula:C17H15N9
Molecular Weight:345.36
Hs Code.:
Mol file:1313725-88-0.mol

Synonyms:Volitinib;Savolitinib;HMPL-504(AZD6094, Volitinib);AZD6094,Volitinib, HMPL-504, Savolitinib;1-[(1S)-1-Imidazo[1,2-a]pyridin-6-ylethyl]-6-(1-methyl-1H-pyrazol-4-yl)-1H-1,2,3-triazolo[4,5-b]pyrazine;(S)-1-(1-(imidazo[1,2-a]pyridin-6-yl)ethyl)-6-(1-methyl-1H-pyrazol-4-yl)-1H-[1,2,3]triazolo[4,5-b]pyrazine

Suppliers and Price of Volitinib

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
Savolitinib
100mg
$ 1215.00

DC Chemicals
Volitinib(Savolitinib) >98%
1 g
$ 2400.00

Crysdot
Savolitinib 98+%
10mg
$ 283.00

Crysdot
Savolitinib 98+%
50mg
$ 665.00

Crysdot
Savolitinib 98+%
100mg
$ 1075.00

ChemScene
Savolitinib 99.56%
100mg
$ 850.00

ChemScene
Savolitinib 99.56%
50mg
$ 490.00

ChemScene
Savolitinib 99.56%
10mg
$ 150.00

ChemScene
Savolitinib 99.56%
5mg
$ 100.00

Biosynth Carbosynth
Volitinib
5 mg
$ 100.00

Total 38 raw suppliers

Chemical Property of Volitinib

Chemical Property:

PKA:5.67±0.50(Predicted)
PSA：91.61000
Density:1.55±0.1 g/cm3(Predicted)
LogP:1.87880
Storage Temp.:-20°C Freezer
Solubility.:DMSO (Slightly), Methanol (Slightly)

Purity/Quality:

99% ^*data from raw suppliers

Savolitinib ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Uses Savolitinib is a potent and highly selective c-Met inhibitor. Savoltinib demonstrated anti-tumor efficacy in a panel of cMet-dysregulated gastric cancer PDX models. Savolitinib also demonstrated good antitmuor activities.

Technology Process of Volitinib

There total 18 articles about Volitinib which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 5-bromo-3-[(1S)-1-imidazo[1,2-a]pyridin-1-ium-6-ylethyl]triazolo[4,5-b]pyrazine chloride

: 761446-44-0
1-methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole

: 1313725-88-0
savolitinib

Guidance literature:: With bis(di-tert-?butyl(4-?dimethylaminophenyl)?phosphine)?dichloropalladium(II); potassium carbonate; iso-butanol; In water; at 65 ℃; for 2h; Reagent/catalyst; Solvent; Inert atmosphere;
DOI:10.1021/acs.joc.8b02351

Reference yield:

: (S)-6-bromo-1-(1-(imidazo[1,2-a]pyridin-6-yl)ethyl)-1H-[1,2,3]triazolo[4,5-b]pyrazine hydrochloride

: 761446-44-0
1-methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole

: 1313725-88-0
savolitinib

Guidance literature:: (S)-6-bromo-1-(1-(imidazo[1,2-a]pyridin-6-yl)ethyl)-1H-[1,2,3]triazolo[4,5-b]pyrazine hydrochloride; 1-methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole; With potassium carbonate; In water; iso-butanol; for 0.0833333h; Inert atmosphere;

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; palladium; In water; iso-butanol; at 30 - 65 ℃; for 2h; Inert atmosphere;

Reference yield:

: 1259603-82-1,1259780-63-6
(1S)-1-imidazo[1,2-a]pyridin-6-ylethanamine

: 1313725-88-0
savolitinib

Guidance literature:: Multi-step reaction with 3 steps

1.1: N-ethyl-N,N-diisopropylamine; 1-methyl-pyrrolidin-2-one / 50 h / 120 °C / Inert atmosphere

2.1: acetic acid; sodium nitrite / water / 4 h / 5 - 20 °C

2.2: 3 h / 0 - 10 °C

3.1: potassium carbonate; bis(di-tert-?butyl(4-?dimethylaminophenyl)?phosphine)?dichloropalladium(II); iso-butanol / water / 2 h / 65 °C / Inert atmosphere

With 1-methyl-pyrrolidin-2-one; bis(di-tert-?butyl(4-?dimethylaminophenyl)?phosphine)?dichloropalladium(II); potassium carbonate; acetic acid; N-ethyl-N,N-diisopropylamine; iso-butanol; sodium nitrite; In water; 3.1: |Suzuki-Miyaura Coupling;
DOI:10.1021/acs.joc.8b02351