(E)-α-[(TriphenylMethoxy)iMino]-2-[(triphenylMethyl)aMino]-4-thiazoleacetic Acid

Base Information

Chemical Name:(E)-α-[(TriphenylMethoxy)iMino]-2-[(triphenylMethyl)aMino]-4-thiazoleacetic Acid
CAS No.:69689-81-2
Molecular Formula:C43H33N3O3S
Molecular Weight:671.819
Hs Code.:
Mol file:69689-81-2.mol

Synonyms:(E)-2-(TrityloxyiMino)-2-[2-(tritylaMino)thiazol-4-yl]acetic Acid;(E)-α-[(TriphenylMethoxy)iMino]-2-[(triphenylMethyl)aMino]-4-thiazoleacetic Acid

Suppliers and Price of (E)-α-[(TriphenylMethoxy)iMino]-2-[(triphenylMethyl)aMino]-4-thiazoleacetic Acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
(E)-2-(Trityloxyimino)-2-[2-(tritylamino)thiazol-4-yl]aceticAcid
250mg
$ 1320.00

Medical Isotopes, Inc.
(E)-2-(Trityloxyimino)-2-[2-(tritylamino)thiazol-4-yl]aceticAcid
25 mg
$ 650.00

Total 4 raw suppliers

Chemical Property of (E)-α-[(TriphenylMethoxy)iMino]-2-[(triphenylMethyl)aMino]-4-thiazoleacetic Acid

Chemical Property:

Boiling Point:832.8±75.0 °C(Predicted)
PKA:2.38±0.41(Predicted)
PSA：112.05000
Density:1.19±0.1 g/cm3(Predicted)
LogP:9.41750
Solubility.:Dimethyl Formamide, Dimethyl Sulfoxide

Purity/Quality:

≥95% ^*data from raw suppliers

(E)-2-(Trityloxyimino)-2-[2-(tritylamino)thiazol-4-yl]aceticAcid ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Uses Intermediate in the preparation of (E)-Cefdinir (C242665).

Technology Process of (E)-α-[(TriphenylMethoxy)iMino]-2-[(triphenylMethyl)aMino]-4-thiazoleacetic Acid

There total 2 articles about (E)-α-[(TriphenylMethoxy)iMino]-2-[(triphenylMethyl)aMino]-4-thiazoleacetic Acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 69689-79-8
(2-tritylamino-thiazol-4-yl)-(E)-trityloxyimino-acetic acid ethyl ester

: 69689-81-2
2-(2-tritylaminothiazol-4-yl)-2-(Z)-trityloxyiminoacetic acid

Guidance literature:: With sodium hydroxide; water; In 1,4-dioxane; at 105 ℃; for 24h; Heating / reflux;

Reference yield:

: 64513-00-4
2-(2-amino-4-thiazolyl)-2-(Z)-hydroxyimino-acetic acid ethyl ester

: 69689-81-2
2-(2-tritylaminothiazol-4-yl)-2-(Z)-trityloxyiminoacetic acid

Guidance literature:: Multi-step reaction with 2 steps

1: Et₃N / CHCl₃ / 1 h / 20 °C

2: aq. NaOH / dioxane / 0.33 h / Heating

With sodium hydroxide; triethylamine; In 1,4-dioxane; chloroform;
DOI:10.1016/0040-4020(78)89034-6