Benzeneacetic acid, 4-chloro-a-[[2-[[[(1,1-dimethylethoxy)carbonyl]amino]iminomethyl]benzo[b]thien-6-yl]oxy]-, methyl ester

Base Information

• Chemical Name: Benzeneacetic acid, 4-chloro-a-[[2-[[[(1,1-dimethylethoxy)carbonyl]amino]iminomethyl]benzo[b]thien-6-yl]oxy]-, methyl ester
• CAS No.: 947590-61-6
• Molecular Formula: C₂₃H₂₃ClN₂O₅S
• Molecular Weight: 474.965
• Mol file: 947590-61-6.mol

Synonyms:Benzeneacetic acid, 4-chloro-a-[[2-[[[(1,1-dimethylethoxy)carbonyl]amino]iminomethyl]benzo[b]thien-6-yl]oxy]-, methyl ester

Chemical Property of Benzeneacetic acid, 4-chloro-a-[[2-[[[(1,1-dimethylethoxy)carbonyl]amino]iminomethyl]benzo[b]thien-6-yl]oxy]-, methyl ester

Chemical Property:

Purity/Quality:

4-CHLORO-ALPHA-[[2-[[[(1,1-DIMETHYLETHOXY)CARBONYL]AMINO]IMINOMETHYL]BENZO[B]THIEN-6-YL]OXY]BENZENEACETIC ACID METHYL ESTER 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Benzeneacetic acid, 4-chloro-a-[[2-[[[(1,1-dimethylethoxy)carbonyl]amino]iminomethyl]benzo[b]thien-6-yl]oxy]-, methyl ester

There total 1 articles about Benzeneacetic acid, 4-chloro-a-[[2-[[[(1,1-dimethylethoxy)carbonyl]amino]iminomethyl]benzo[b]thien-6-yl]oxy]-, methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

N'-t-Boc-6-hydroxybenzothiophene-2-carboxamidine (947590-65-0) + methyl 4-chloromandelate (32174-34-8,63096-36-6,104420-79-3,13305-19-6) → C23H23ClN2O5S (947590-61-6)

Guidance literature:

With triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; at 20 ℃; for 15.25h;

Reference yield:

C23H23ClN2O5S (947590-61-6) + trifluoroacetic acid (76-05-1) → (2-carbamimidoylbenzo[b]thiophen-6-yloxy)-2-(4-chlorophenyl)acetic acid methyl ester trifluoroacetate (1209467-11-7)

Guidance literature:

In dichloromethane; at 20 ℃;

DOI:10.1021/jm901475e

upstream raw materials:

N'-t-Boc-6-hydroxybenzothiophene-2-carboxamidine

methyl 4-chloromandelate

Downstream raw materials:

(2-carbamimidoylbenzo[b]thiophen-6-yloxy)-2-(4-chlorophenyl)acetic acid methyl ester trifluoroacetate