2(3H)-Benzofuranone, 6-aMino-5-(1,1-diMethylethyl)-3,3-diMethyl-

Base Information

Chemical Name:2(3H)-Benzofuranone, 6-aMino-5-(1,1-diMethylethyl)-3,3-diMethyl-
CAS No.:1246213-40-0
Molecular Formula:C₁₄H₁₉NO₂
Molecular Weight:233.31
Hs Code.:2932209090
Mol file:1246213-40-0.mol

Synonyms:2(3H)-Benzofuranone, 6-aMino-5-(1,1-diMethylethyl)-3,3-diMethyl-

Suppliers and Price of 2(3H)-Benzofuranone, 6-aMino-5-(1,1-diMethylethyl)-3,3-diMethyl-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
6-Amino-5-(1,1-dimethylethyl)-3,3-dimethyl-2(3H)-benzofuranone
1mg
$ 75.00

TRC
6-Amino-5-(1,1-dimethylethyl)-3,3-dimethyl-2(3H)-benzofuranone
10mg
$ 615.00

Crysdot
6-Amino-5-(tert-butyl)-3,3-dimethylbenzofuran-2(3H)-one 95+%
1g
$ 772.00

Chemenu
6-amino-5-(tert-butyl)-3,3-dimethylbenzofuran-2(3H)-one 95%
1g
$ 729.00

American Custom Chemicals Corporation
6-AMINO-5-(TERT-BUTYL)-3,3-DIMETHYLBENZOFURAN-2(3H)-ONE 95.00%
5MG
$ 504.48

Total 6 raw suppliers

Chemical Property of 2(3H)-Benzofuranone, 6-aMino-5-(1,1-diMethylethyl)-3,3-diMethyl-

Chemical Property:

PSA：52.32000
LogP:3.34410
Storage Temp.:2-8°C
Solubility.:Chloroform; Dichloromethane; Methanol

Purity/Quality:

≥95% ^*data from raw suppliers

6-Amino-5-(1,1-dimethylethyl)-3,3-dimethyl-2(3H)-benzofuranone ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Uses 6-Amino-5-(1,1-dimethylethyl)-3,3-dimethyl-2(3H)-benzofuranone is an intermediate in synthesizing Ivacaftor Carboxylic Acid (I940605). It is an impurity of Ivacaftor (I940600); a drug used in the treatment of cystic fibrosis.

Technology Process of 2(3H)-Benzofuranone, 6-aMino-5-(1,1-diMethylethyl)-3,3-diMethyl-

There total 1 articles about 2(3H)-Benzofuranone, 6-aMino-5-(1,1-diMethylethyl)-3,3-diMethyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 1246213-39-7
5-tert-butyl-3,3-dimethyl-6-nitrobenzofuran-2(3H)-one

: 1246213-40-0
6-amino-5-tert-butyl-3,3-dimethylbenzofuran-2(3H)-one

Guidance literature:: With hydrogen; 5% Pd(II)/C(eggshell); In methanol; Product distribution / selectivity; Inert atmosphere;

Reference yield:

: 1246213-40-0
6-amino-5-tert-butyl-3,3-dimethylbenzofuran-2(3H)-one

: 13721-01-2
4-oxo-1,4-dihydroquinoline-3-carboxylic acid

: 1246213-41-1
N-(5-tert-butyl-3,3-dimethyl-2-oxo-2,3-dihydrobenzofuran-6-yl)-4-oxo-1,4-dihydroquinoline-3-carboxamide

Guidance literature:: 4-oxo-1,4-dihydroquinoline-3-carboxylic acid; With HATU; In acetonitrile; at 20 ℃; for 1h;

6-amino-5-tert-butyl-3,3-dimethylbenzofuran-2(3H)-one; With N-ethyl-N,N-diisopropylamine; In acetonitrile; at 20 - 45 ℃; Product distribution / selectivity;