3,5-Difluoro-4-hydroxyphenylboronic acid

Base Information

• Chemical Name: 3,5-Difluoro-4-hydroxyphenylboronic acid
• CAS No.: 1132666-81-9
• Molecular Formula: C6H5BF2O3
• Molecular Weight: 173.912
• Hs Code.: 2931900090
• Mol file: 1132666-81-9.mol

Synonyms:3,5-Difluoro-4-hydroxyphenylboronic acid

Chemical Property of 3,5-Difluoro-4-hydroxyphenylboronic acid

Chemical Property:

• PSA: 60.69000
• LogP: -0.64980
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

98% ^*data from raw suppliers

3,5-Difluoro-4-hydroxyphenylboronicAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3,5-Difluoro-4-hydroxyphenylboronic acid

There total 1 articles about 3,5-Difluoro-4-hydroxyphenylboronic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 39.7%

hydrogenchloride (7647-01-0,15364-23-5) + Triisopropyl borate (5419-55-6) + 4-bromo-1,3-difluoro-2-(methoxymethoxy)benzene → (3,5-difluoro-4-hydroxyphenyl)boronic acid (1132666-81-9)

Guidance literature:

Triisopropyl borate; 4-bromo-1,3-difluoro-2-(methoxymethoxy)benzene; With n-butyllithium; In tetrahydrofuran; at -78 ℃; for 1h;

hydrogenchloride; In water; at 0 - 20 ℃; for 0.5h;

Reference yield: 77.0%

(3,5-difluoro-4-hydroxyphenyl)boronic acid (1132666-81-9) + C14H13BrFN3O2 → 5-(2-amino-5-(3,5-difluoro-4-hydroxyphenyl)pyridin-3-yl)-2-fluoro-N-(2-hydroxyethyl)benzamide

Guidance literature:

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; caesium carbonate; In ethanol; water; at 85 ℃; for 1h; Inert atmosphere; Microwave irradiation;

DOI:10.1021/acsmedchemlett.9b00082

Reference yield: 76.0%

(3,5-difluoro-4-hydroxyphenyl)boronic acid (1132666-81-9) + 4-(2-amino-5-bromo-3-pyridyl)phenol (1314883-36-7) → 4-(6-amino-5-(4-hydroxyphenyl)pyridin-3-yl)-2,6-difluorophenol

Guidance literature:

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; caesium carbonate; In ethanol; water; at 85 ℃; for 1h; Inert atmosphere; Microwave irradiation;

DOI:10.1021/acsmedchemlett.9b00082

upstream raw materials:

hydrogenchloride

Triisopropyl borate

Refernces