5-bromo-1-methyl-3-(5-(4-methylpiperazin-1-yl)pyridin-2-ylamino)pyridin-2(1H)-one

Base Information

Chemical Name:5-bromo-1-methyl-3-(5-(4-methylpiperazin-1-yl)pyridin-2-ylamino)pyridin-2(1H)-one
CAS No.:1178884-45-1
Molecular Formula:C16H20BrN5O
Molecular Weight:378.272
Hs Code.:
Mol file:1178884-45-1.mol

Synonyms:5-bromo-1-methyl-3-(5-(4-methylpiperazin-1-yl)pyridin-2-ylamino)pyridin-2(1H)-one

Suppliers and Price of 5-bromo-1-methyl-3-(5-(4-methylpiperazin-1-yl)pyridin-2-ylamino)pyridin-2(1H)-one

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Matrix Scientific
5-Bromo-1-methyl-3-((5-(4-methylpiperazin-1-yl)pyridin-2-yl)amino)pyridin-2(1H)-one 97%
10g
$ 7200.00

Matrix Scientific
5-Bromo-1-methyl-3-((5-(4-methylpiperazin-1-yl)pyridin-2-yl)amino)pyridin-2(1H)-one 97%
5g
$ 4860.00

Crysdot
5-Bromo-1-methyl-3-((5-(4-methylpiperazin-1-yl)pyridin-2-yl)amino)pyridin-2(1H)-one 97%
1g
$ 1050.00

Alichem
5-Bromo-1-methyl-3-((5-(4-methylpiperazin-1-yl)pyridin-2-yl)amino)pyridin-2(1H)-one
1g
$ 1155.00

Total 3 raw suppliers

Chemical Property of 5-bromo-1-methyl-3-(5-(4-methylpiperazin-1-yl)pyridin-2-ylamino)pyridin-2(1H)-one

Chemical Property:

Boiling Point:509.6±50.0 °C(Predicted)
PKA:7.37±0.42(Predicted)
PSA：53.40000
Density:1.498±0.06 g/cm3(Predicted)
LogP:2.11410

Purity/Quality:

98%min ^*data from raw suppliers

5-Bromo-1-methyl-3-((5-(4-methylpiperazin-1-yl)pyridin-2-yl)amino)pyridin-2(1H)-one 97% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 5-bromo-1-methyl-3-(5-(4-methylpiperazin-1-yl)pyridin-2-ylamino)pyridin-2(1H)-one

There total 11 articles about 5-bromo-1-methyl-3-(5-(4-methylpiperazin-1-yl)pyridin-2-ylamino)pyridin-2(1H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

: 571189-49-6
5-(4-methyl-piperazin-1-yl)pyridin-2-ylamine

: 14529-54-5
3,5-dibromo-1-methyl-1H-pyridin-2-one

: 1178884-45-1
5-bromo-1-methyl-3-((5-(4-methylpiperazin-1-yl)pyridin-2-yl)amino)pyridin-2(1H)-one

Guidance literature:: With caesium carbonate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In 1,4-dioxane; at 100 ℃; for 0.5h; Inert atmosphere; sealed tube;

Reference yield: 4.0%

: 571189-49-6
5-(4-methyl-piperazin-1-yl)pyridin-2-ylamine

: 5-bromo-3-iodo-1-methylpyridin-2(1H)-one

: 1178884-45-1
5-bromo-1-methyl-3-((5-(4-methylpiperazin-1-yl)pyridin-2-yl)amino)pyridin-2(1H)-one

Guidance literature:: With copper(l) iodide; caesium carbonate; L-proline; In 1,4-dioxane; at 120 ℃; for 18h; Inert atmosphere;

Reference yield:

: 571189-16-7
4-(6-nitropyridin-3-yl)-piperazine-1-carboxylic acid tert-butyl ester

: 1178884-45-1
5-bromo-1-methyl-3-((5-(4-methylpiperazin-1-yl)pyridin-2-yl)amino)pyridin-2(1H)-one

Guidance literature:: Multi-step reaction with 4 steps

1: palladium 10% on activated carbon; hydrogen / water; ethanol / 16 h / 20 °C

2: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; caesium carbonate / 1,4-dioxane / 15 h / Inert atmosphere; Reflux

3: hydrogenchloride / 1,4-dioxane; dichloromethane / 4 h / 20 °C

4: sodium tris(acetoxy)borohydride; acetic acid / methanol / 1 h / 20 °C

With hydrogenchloride; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; palladium 10% on activated carbon; hydrogen; sodium tris(acetoxy)borohydride; caesium carbonate; acetic acid; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In 1,4-dioxane; methanol; ethanol; dichloromethane; water;
DOI:10.1021/acs.jmedchem.7b01712