[R-(R*,S*)]-β-[(1-Phenylethyl)(phenylMethyl)aMino]-4-(phenylMethoxy)-benzenepropanoic Acid Methyl Ester

Base Information

• Chemical Name: [R-(R*,S*)]-β-[(1-Phenylethyl)(phenylMethyl)aMino]-4-(phenylMethoxy)-benzenepropanoic Acid Methyl Ester
• CAS No.: 134430-95-8
• Molecular Formula: C32H33NO3
• Molecular Weight: 479.619
• Mol file: 134430-95-8.mol

Synonyms:(βS)-β-[[(1R)-1-Phenylethyl](phenylMethyl)aMino]-4-(phenylMethoxy)-benzenepropanoic Acid Methyl Ester;[R-(R*,S*)]-β-[(1-Phenylethyl)(phenylMethyl)aMino]-4-(phenylMethoxy)-benzenepropanoic Acid Methyl Ester

Chemical Property of [R-(R*,S*)]-β-[(1-Phenylethyl)(phenylMethyl)aMino]-4-(phenylMethoxy)-benzenepropanoic Acid Methyl Ester

Chemical Property:

• PSA: 38.77000
• LogP: 7.13320
• Solubility.: Dichloromethane

Purity/Quality:

98%min ^*data from raw suppliers

(βS)-β-[[(1R)-1-Phenylethyl](phenylmethyl)amino]-4-(phenylmethoxy)-benzenepropanoicAcidMethylEster ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: (βS)-β-[[(1R)-1-Phenylethyl](phenylmethyl)amino]-4-(phenylmethoxy)-benzenepropanoic Acid Methyl Ester (cas# 134430-95-8) is a compound useful in organic synthesis.

Technology Process of [R-(R*,S*)]-β-[(1-Phenylethyl)(phenylMethyl)aMino]-4-(phenylMethoxy)-benzenepropanoic Acid Methyl Ester

There total 2 articles about [R-(R*,S*)]-β-[(1-Phenylethyl)(phenylMethyl)aMino]-4-(phenylMethoxy)-benzenepropanoic Acid Methyl Ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

(E)-methyl 3-(4-(benzyloxy)phenyl)acrylate (84184-51-0) + (R)-N-benzyl-1-phenylethylamine (38235-77-7) → methyl (3R,αR)-3-(N-benzyl-N-α-methylbenzylamino)-3-(4-benzyloxyphenyl)propanoate + methyl (3S,αR)-3-(N-benzyl-N-α-methylbenzylamino)-3-(4-benzyloxyphenyl)propanoate (134430-95-8)

Guidance literature:

With n-butyllithium; In tetrahydrofuran; hexane; at -78 ℃;

DOI:10.1016/j.tetasy.2006.05.008

Reference yield:

(E)-methyl 3-(4-(benzyloxy)phenyl)acrylate (84184-51-0) + (R)-N-benzyl-1-phenylethylamine (38235-77-7) → methyl (3S,αR)-3-(N-benzyl-N-α-methylbenzylamino)-3-(4-benzyloxyphenyl)propanoate (134430-95-8)

Guidance literature:

With n-butyllithium; Yield given. Multistep reaction; 1.) hexane, THF, 0 deg C, 15 min, 2.) -78 deg C, 15 min;

DOI:10.1016/S0957-4166(00)82354-X

Reference yield: 100.0%

methyl (3S,αR)-3-(N-benzyl-N-α-methylbenzylamino)-3-(4-benzyloxyphenyl)propanoate (134430-95-8) → methyl (3S)-3-amino-3-(4-hydroxyphenyl)propanoate (177966-65-3)

Guidance literature:

With hydrogen; acetic acid; palladium dihydroxide; In methanol; water; at 20 ℃; for 18h; under 760 Torr;

DOI:10.1016/S0957-4166(00)82354-X

upstream raw materials:

(E)-methyl 3-(4-(benzyloxy)phenyl)acrylate

(R)-N-benzyl-1-phenylethylamine

Downstream raw materials:

methyl (3S)-3-amino-3-(4-hydroxyphenyl)propanoate

(S)-β-tyrosine hydrochloride

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