7-Chloro-2-Methyl-1H-pyrrolo[2,3-c]pyridine

Base Information

• Chemical Name: 7-Chloro-2-Methyl-1H-pyrrolo[2,3-c]pyridine
• CAS No.: 874013-97-5
• Molecular Formula: C₈H₇ClN₂
• Molecular Weight: 166.61
• Hs Code.: 2933990090
• Mol file: 874013-97-5.mol

Synonyms:7-Chloro-2-Methyl-1H-pyrrolo[2,3-c]pyridine;7-Chloro-2-Methyl-6-azaindole;7-Chloro-2-methyl-1H-pyrrolo[2,3-c]pyrdine

Chemical Property of 7-Chloro-2-Methyl-1H-pyrrolo[2,3-c]pyridine

Chemical Property:

• PSA: 28.68000
• LogP: 2.52470
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

7-Chloro-2-methyl-1H-pyrrolo[2,3-c]pyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 7-Chloro-2-Methyl-1H-pyrrolo[2,3-c]pyridine

There total 3 articles about 7-Chloro-2-Methyl-1H-pyrrolo[2,3-c]pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

7-chloro-2-methyl-1-(phenylsulfonyl)-1H-pyrrolo[2,3-c]pyridine (1415124-77-4) → 7-chloro-2-methyl-1H-pyrrolo[2,3-c]pyridine (874013-97-5)

Guidance literature:

With sodium hydroxide; In ethanol; at 20 ℃; for 16h;

Reference yield: 28.0%

2-Chloro-3-nitropyridine (5470-18-8,34515-82-7) + isopropylmagnesium bromide (920-39-8) → 7-chloro-2-methyl-1H-pyrrolo[2,3-c]pyridine (874013-97-5)

Guidance literature:

2-Chloro-3-nitropyridine; isopropylmagnesium bromide; In tetrahydrofuran; at -78 - -20 ℃; for 18h;

With water; ammonium chloride; In tetrahydrofuran;

Reference yield: 28.0%

2-Chloro-3-nitropyridine (5470-18-8,34515-82-7) + 1-propenylmagnesium bromide (13154-14-8,13154-15-9,14092-04-7,1730-25-2) → 7-chloro-2-methyl-1H-pyrrolo[2,3-c]pyridine (874013-97-5)

Guidance literature:

In tetrahydrofuran; at -78 - -20 ℃; for 18h;

DOI:10.1248/cpb.c13-00878

upstream raw materials:

2-Chloro-3-nitropyridine

isopropylmagnesium bromide

7-chloro-2-methyl-1-(phenylsulfonyl)-1H-pyrrolo[2,3-c]pyridine

1-propenylmagnesium bromide