Technology Process of 4-(2-Hydroxyethyl)phenyl Methanesulfonate
There total 8 articles about 4-(2-Hydroxyethyl)phenyl Methanesulfonate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 7 steps
1: 3.1 g / thionyl chloride / diethyl ether / 2 h / Heating
2: 4.2 g / n-butyl-lithium / hexane; tetrahydrofuran / 1.) -23 deg C, 1.5 h, 2.) 0 deg C, 14 h
3: 3.6 g / mercuric oxide, mercuric chloride / acetonitrile / 6 h / Heating
4: 1.) Raney nickel, 2.) hydrogen / 2.) palladium on charcoal / 1.) ethanol, reflux, 15 - 20 min, 2.) methanol,
5: 2.5 g / triethylamine / CH2Cl2 / 0.17 h / 0 - 10 °C
6: 1.12 g / aq. hydrochloric acid / tetrahydrofuran / 0.67 h / 18 °C
7: 1.83 g / sodium borohydride / methanol / 0.17 h / Ambient temperature
With
hydrogenchloride; sodium tetrahydroborate; n-butyllithium; thionyl chloride; hydrogen; nickel; triethylamine; mercury dichloride; mercury(II) oxide;
palladium on activated charcoal;
In
tetrahydrofuran; methanol; diethyl ether; hexane; dichloromethane; acetonitrile;
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 1.) Raney nickel, 2.) hydrogen / 2.) palladium on charcoal / 1.) ethanol, reflux, 15 - 20 min, 2.) methanol,
2: 2.5 g / triethylamine / CH2Cl2 / 0.17 h / 0 - 10 °C
3: 1.12 g / aq. hydrochloric acid / tetrahydrofuran / 0.67 h / 18 °C
4: 1.83 g / sodium borohydride / methanol / 0.17 h / Ambient temperature
With
hydrogenchloride; sodium tetrahydroborate; hydrogen; nickel; triethylamine;
palladium on activated charcoal;
In
tetrahydrofuran; methanol; dichloromethane;
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 3.6 g / mercuric oxide, mercuric chloride / acetonitrile / 6 h / Heating
2: 1.) Raney nickel, 2.) hydrogen / 2.) palladium on charcoal / 1.) ethanol, reflux, 15 - 20 min, 2.) methanol,
3: 2.5 g / triethylamine / CH2Cl2 / 0.17 h / 0 - 10 °C
4: 1.12 g / aq. hydrochloric acid / tetrahydrofuran / 0.67 h / 18 °C
5: 1.83 g / sodium borohydride / methanol / 0.17 h / Ambient temperature
With
hydrogenchloride; sodium tetrahydroborate; hydrogen; nickel; triethylamine; mercury dichloride; mercury(II) oxide;
palladium on activated charcoal;
In
tetrahydrofuran; methanol; dichloromethane; acetonitrile;
