modipafant

Base Information

Chemical Name:modipafant
CAS No.:122956-68-7
Molecular Formula:C34H29 Cl N6 O3
Molecular Weight:605.096
Hs Code.:
Mol file:122956-68-7.mol

Synonyms:1H-Imidazo[4,5-c]pyridine,3-pyridinecarboxylic acid deriv.; UK 74505

Suppliers and Price of modipafant

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
rac-Modipafant
100mg
$ 9625.00

Medical Isotopes, Inc.
rac-Modipafant
25 mg
$ 6250.00

American Custom Chemicals Corporation
RAC-MODIPAFANT 95.00%
10MG
$ 6479.55

Total 6 raw suppliers

Chemical Property of modipafant

Chemical Property:

Boiling Point:°Cat760mmHg
PKA:12.14±0.70(Predicted)
Flash Point:°C
PSA：114.52000
Density:1.34g/cm³
LogP:7.32950

Purity/Quality:

97% ^*data from raw suppliers

rac-Modipafant ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Uses Modipafant is a novel and selective PAF antagonist with potent and prolonged oral activity.

Technology Process of modipafant

There total 10 articles about modipafant which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 31.0%

: N-(pyridin-2-yl)-3-aminocrotonamide

: 89-98-5
2-chloro-benzaldehyde

: 122957-08-8
ethyl 4'-(2-methylimidazo[4,5-c]pyridin-1-yl)benzoylacetate

: 122956-68-7,122957-06-6
(+/-)-Modipafant

Guidance literature:: In ethanol;

Reference yield: 31.0%

: 89-98-5
2-chloro-benzaldehyde

: 60155-47-7
N-(2-pyridyl)-3-aminocrotonamide

: 122957-08-8
ethyl 4'-(2-methylimidazo[4,5-c]pyridin-1-yl)benzoylacetate

: 122956-68-7,122957-06-6
(+/-)-Modipafant

Guidance literature:: In ethanol; for 8h; Heating;
DOI:10.1021/jm00095a005

Reference yield:

: 13091-23-1
4-chloro-3-nitropyridine

: 122956-68-7,122957-06-6
(+/-)-Modipafant

Guidance literature:: Multi-step reaction with 5 steps

1: 87 percent / ethanol / 18 h / 20 °C

2: 98 percent / H₂ / 10percent Pd/C / methanol; CH₂Cl₂ / 2 h / 20 °C / 1551.4 Torr

3: 81 percent / acetic acid / 2 h / 90 °C

4: 1.) Zn, 2.) 20percent aq. TFA / 1.) THF, reflux, 10 min, 2.) CH₂Cl₂, RT, 15 min

5: 31 percent / ethanol / 8 h / Heating

With hydrogen; trifluoroacetic acid; zinc; palladium on activated charcoal; In methanol; ethanol; dichloromethane; acetic acid;
DOI:10.1021/jm00095a005