2-Bromo-4-fluorostyrene

Base Information

• Chemical Name: 2-Bromo-4-fluorostyrene
• CAS No.: 1221684-51-0
• Molecular Formula: C8H6BrF
• Molecular Weight: 201.038
• Hs Code.: 2903999090
• Mol file: 1221684-51-0.mol

Synonyms:2-Bromo-4-fluorostyrene;2-Bromo-4-fluoro-1-vinylbenzene, 2-Bromo-1-ethenyl-4-fluorobenzene;2-BroMo-4-fluoro-1-vinylbenzene;2-BroMo-1-ethenyl-4-fluorobenzene

Chemical Property of 2-Bromo-4-fluorostyrene

Chemical Property:

• Boiling Point: 204.6±20.0℃ (760 Torr)
• Flash Point: 80.2±16.6℃
• PSA: 0.00000
• Density: 1.480±0.06 g/cm3 (20 oC 760 Torr)
• LogP: 3.23120

Purity/Quality:

97% ^*data from raw suppliers

2-Bromo-1-ethenyl-4-fluorobenzene ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Bromo-4-fluorostyrene

There total 4 articles about 2-Bromo-4-fluorostyrene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.6%

2-bromo-4-fluorobenzaldehyde (59142-68-6) + methyl-triphenylphosphonium iodide (2065-66-9) → 2-bromo-4-fluoro-1-vinylbenzene (1221684-51-0)

Guidance literature:

methyl-triphenylphosphonium iodide; With n-butyllithium; In tetrahydrofuran; at 0 ℃; for 0.25h; Inert atmosphere;

2-bromo-4-fluorobenzaldehyde; In tetrahydrofuran; for 2.25h; Inert atmosphere; Cooling with ice;

DOI:10.1021/ja306446m

Reference yield:

2-bromo-4-fluorobenzaldehyde (59142-68-6) + Methyltriphenylphosphonium bromide (1779-49-3) → 2-bromo-4-fluoro-1-vinylbenzene (1221684-51-0)

Guidance literature:

Methyltriphenylphosphonium bromide; With n-butyllithium; In tetrahydrofuran; at 0 ℃; for 1h; Inert atmosphere;

2-bromo-4-fluorobenzaldehyde; In tetrahydrofuran; at -78 - 20 ℃; for 3.5h; Inert atmosphere;

DOI:10.1002/asia.201600593

Reference yield:

2-bromo-4-fluorobenzonitrile (36282-26-5) → 2-bromo-4-fluoro-1-vinylbenzene (1221684-51-0)

Guidance literature:

Multi-step reaction with 2 steps

1.1: diisobutylaluminium hydride / toluene / 12 h / 0 - 45 °C / Inert atmosphere

1.2: 20 °C / Inert atmosphere

2.1: n-butyllithium / tetrahydrofuran / 0.5 h / 0 °C / Inert atmosphere

2.2: 2 h / 0 - 20 °C / Inert atmosphere

With n-butyllithium; diisobutylaluminium hydride; In tetrahydrofuran; toluene;

DOI:10.1002/anie.201611853

upstream raw materials:

2-bromo-4-fluorobenzaldehyde

methyl-triphenylphosphonium iodide

Methyltriphenylphosphonium bromide

4-fluorobenzonitrile

Downstream raw materials:

5-fluoro-2-vinyl-benzaldehyde