Lasmiditan succinate (USAN)

Base Information

• Chemical Name: Lasmiditan succinate (USAN)
• CAS No.: 439239-92-6
• Molecular Formula: 0C₄H₆O₄*C₁₉H₁₈F₃N₃O₂
• Molecular Weight: 436.411
• Mol file: 439239-92-6.mol

Synonyms:2,4,6-trifluoro-N-{6-[(1-methylpiperidine-4-yl)carbonyl]pyridin-2-yl}benzamide hemisuccinate

Chemical Property of Lasmiditan succinate (USAN)

Chemical Property:

• PSA: 206.18000
• LogP: 7.13100

Purity/Quality:

99% ,99.9%, ^*data from raw suppliers

COL-144(Lasmiditan)succinate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Lasmiditan succinate (USAN)

There total 8 articles about Lasmiditan succinate (USAN) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

Lasmiditan (439239-90-4) + succinic acid (110-15-6) → 2,4,6-trifluoro-N-[6-(1-methylpiperidine-4-carbonyl)pyridin-2-yl]benzamide hemisuccinate (439239-92-6)

Guidance literature:

In acetone; at 20 ℃; for 0.5h; Heating / reflux;

Reference yield: 85.0%

Lasmiditan (439239-90-4) + succinic acid (110-15-6) → 2,4,6-trifluoro-N- [6-(1-methylpiperidine-4-carbonyl)-2-pyridyl]benzamide hemisuccinate (439239-92-6)

Guidance literature:

In ethanol; at 20 - 80 ℃; Inert atmosphere;

Reference yield: 85.0%

2,4,6-trifluoro-N-[6-(1-methylpiperidin-4-ylcarbonyl)-pyridin-2-yl]benzamide hydrochloride (613677-28-4) + succinic acid (110-15-6) → 2,4,6-trifluoro-N- [6-(1-methylpiperidine-4-carbonyl)-2-pyridyl]benzamide hemisuccinate (439239-92-6)

Guidance literature:

2,4,6-trifluoro-N-[6-(1-methylpiperidin-4-ylcarbonyl)-pyridin-2-yl]benzamide hydrochloride; With sodium hydrogencarbonate; In tert-butyl methyl ether; water; at 20 ℃; for 1h;

succinic acid; In ethanol; at 33 - 55 ℃; for 3h; Reagent/catalyst; Solvent; Temperature;

upstream raw materials:

Lasmiditan

succinic acid

4-chloro-1-methylpiperidine

(1-methyl-4-piperidyl)magnesium chloride

Refernces

• 1、 -. "PROCESS FOR PREPARATION OF LASMIDITAN". Paragraph 0096. . Retrieved 2021/08/06.
• 2、 -. "PROCESS FOR PREPARATION OF LASMIDITAN". Paragraph 0186. . Retrieved 2020/06/01.