3-[[[3,5-bis(trifluoromethyl)phenyl]methyl]amino]-4-[(9R)-cinchonan-9-ylamino]-3-Cyclobutene-1,2-dione

Base Information

Chemical Name:3-[[[3,5-bis(trifluoromethyl)phenyl]methyl]amino]-4-[(9R)-cinchonan-9-ylamino]-3-Cyclobutene-1,2-dione
CAS No.:1073917-09-5
Molecular Formula:C32H28F6N4O2
Molecular Weight:614.59
Hs Code.:
Mol file:1073917-09-5.mol

Synonyms:3-[[[3,5-bis(trifluoromethyl)phenyl]methyl]amino]-4-[(9R)-cinchonan-9-ylamino]-3-Cyclobutene-1,2-dione

Suppliers and Price of 3-[[[3,5-bis(trifluoromethyl)phenyl]methyl]amino]-4-[(9R)-cinchonan-9-ylamino]-3-Cyclobutene-1,2-dione

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 2 raw suppliers

Chemical Property of 3-[[[3,5-bis(trifluoromethyl)phenyl]methyl]amino]-4-[(9R)-cinchonan-9-ylamino]-3-Cyclobutene-1,2-dione

Chemical Property:

PSA：74.33000
LogP:6.67240

Purity/Quality:: >95%,>98%e.e. ^*data from raw suppliers

Safty Information:

Pictogram(s):
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Technology Process of 3-[[[3,5-bis(trifluoromethyl)phenyl]methyl]amino]-4-[(9R)-cinchonan-9-ylamino]-3-Cyclobutene-1,2-dione

There total 2 articles about 3-[[[3,5-bis(trifluoromethyl)phenyl]methyl]amino]-4-[(9R)-cinchonan-9-ylamino]-3-Cyclobutene-1,2-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 1073917-05-1
3-((3,5-bis(trifluoromethyl)benzyl)amino)-4-methoxycyclobut-3-ene-1,2-dione

: 9-amino-9-deoxyepicinchonine

: 1073917-09-5
C₃₂H₂₈F₆N₄O₂

Guidance literature:: In methanol; at 20 ℃; for 48h; Inert atmosphere;
DOI:10.1016/j.tetlet.2016.02.008

Reference yield:

: 85068-29-7
3,5-bis-trifluoromethylbenzylamine

: 1073917-09-5
C₃₂H₂₈F₆N₄O₂

Guidance literature:: Multi-step reaction with 2 steps

1: dichloromethane / 24 h / 20 °C / Inert atmosphere

2: methanol / 48 h / 20 °C / Inert atmosphere

In methanol; dichloromethane;
DOI:10.1016/j.tetlet.2016.02.008