1-[1-(DIPHENYLMETHYL)AZETIDIN-3-YL]PIPERAZINE

Base Information

• Chemical Name: 1-[1-(DIPHENYLMETHYL)AZETIDIN-3-YL]PIPERAZINE
• CAS No.: 930782-73-3
• Molecular Formula: C20H25N3
• Molecular Weight: 307.439
• Mol file: 930782-73-3.mol

Synonyms:1-[1-(DIPHENYLMETHYL)AZETIDIN-3-YL]PIPERAZINE;1-(1-benzhydrylazetidin-3-yl)piperazine

Chemical Property of 1-[1-(DIPHENYLMETHYL)AZETIDIN-3-YL]PIPERAZINE

Chemical Property:

• PSA: 18.51000
• LogP: 2.57000

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-[1-(DIPHENYLMETHYL)AZETIDIN-3-YL]PIPERAZINE

There total 4 articles about 1-[1-(DIPHENYLMETHYL)AZETIDIN-3-YL]PIPERAZINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

tert-butyl 4-(1-benzhydrylazetidin-3-yl)piperazine-1-carboxylate (178311-82-5) → 1-(1-benzhydrylazetidin-3-yl)piperazine (930782-73-3)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 12h;

DOI:10.1021/acs.jmedchem.8b01778

Reference yield: 97.0%

piperazine (110-85-0) + 1-benzhydryl-3-azetidinyl methanesulfonate (33301-41-6) → 1-(1-benzhydrylazetidin-3-yl)piperazine (930782-73-3)

Guidance literature:

In acetonitrile; at 80 ℃; for 19h;

Reference yield:

1-benzhydryl-3-azetidinyl methanesulfonate (33301-41-6) → 1-(1-benzhydrylazetidin-3-yl)piperazine (930782-73-3)

Guidance literature:

Multi-step reaction with 2 steps

1: N-ethyl-N,N-diisopropylamine / acetonitrile / 12 h / 20 - 80 °C

2: trifluoroacetic acid / dichloromethane / 12 h / 20 °C

With N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In dichloromethane; acetonitrile;

DOI:10.1021/acs.jmedchem.8b01778

upstream raw materials:

piperazine

1-benzhydryl-3-azetidinyl methanesulfonate

tert-butyl 4-(1-benzhydrylazetidin-3-yl)piperazine-1-carboxylate

Downstream raw materials:

1-[1-(diphenylmethyl)azetidin-3-yl]-4-isobutyrylpiperazine

1-[1-(diphenylmethyl)azetidin-3-yl]-4-(methoxyacetyl)piperazine

1-[1-(diphenylmethyl)azetidin-3-yl]-4-propionylpiperazine

6-[4-(1-Benzhydryl-azetidin-3-yl)-piperazin-1-yl]-3-ethyl-1-phenyl-1H-pyrazolo[3,4-d]pyrimidine

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 930782-73-3 1-[1-(DIPHENYLMETHYL)AZETIDIN-3-YL]PIPERAZINE

Send

Send

Metric Ton KG G Pound L ML

Send

Send