1-(4-fluorophenyl)-5-({3-[4-(1,3-thiazol-2-ylcarbonyl)piperazin-1-yl]azetidin-1-yl}carbonyl)-1H-indole hydrochloride

Base Information

Chemical Name:1-(4-fluorophenyl)-5-({3-[4-(1,3-thiazol-2-ylcarbonyl)piperazin-1-yl]azetidin-1-yl}carbonyl)-1H-indole hydrochloride
CAS No.:1429022-30-9
Molecular Formula:C₂₆H₂₄FN₅O₂S*ClH
Molecular Weight:526.034
Hs Code.:

Synonyms:1-(4-fluorophenyl)-5-({3-[4-(1,3-thiazol-2-ylcarbonyl)piperazin-1-yl]azetidin-1-yl}carbonyl)-1H-indole hydrochloride

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Chemical Property of 1-(4-fluorophenyl)-5-({3-[4-(1,3-thiazol-2-ylcarbonyl)piperazin-1-yl]azetidin-1-yl}carbonyl)-1H-indole hydrochloride

Chemical Property:

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Technology Process of 1-(4-fluorophenyl)-5-({3-[4-(1,3-thiazol-2-ylcarbonyl)piperazin-1-yl]azetidin-1-yl}carbonyl)-1H-indole hydrochloride

There total 12 articles about 1-(4-fluorophenyl)-5-({3-[4-(1,3-thiazol-2-ylcarbonyl)piperazin-1-yl]azetidin-1-yl}carbonyl)-1H-indole hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1252765-13-1
JNJ-42226314

: 1429022-30-9
1-(4-fluorophenyl)-5-({3-[4-(1,3-thiazol-2-ylcarbonyl)piperazin-1-yl]azetidin-1-yl}carbonyl)-1H-indole hydrochloride

Guidance literature:: With hydrogenchloride; In dichloromethane; water; for 1h; Inert atmosphere;

Reference yield:

: 1011-65-0
5-methoxycarbonylindole

: 1429022-30-9
1-(4-fluorophenyl)-5-({3-[4-(1,3-thiazol-2-ylcarbonyl)piperazin-1-yl]azetidin-1-yl}carbonyl)-1H-indole hydrochloride

Guidance literature:: Multi-step reaction with 4 steps

1: potassium carbonate; copper(l) iodide / 2.5 h / 220 °C / Microwave irradiation

2: lithium hydroxide / tetrahydrofuran; water / 18 h / 55 °C / Inert atmosphere

3: triethylamine; HATU / dichloromethane / 72 h / 20 °C / Inert atmosphere

4: hydrogenchloride / dichloromethane; water / 1 h / Inert atmosphere

With hydrogenchloride; copper(l) iodide; potassium carbonate; triethylamine; HATU; lithium hydroxide; In tetrahydrofuran; dichloromethane; water;

Reference yield:

: 352-34-1
4-fluoro-1-iodobenzene

: 1429022-30-9
1-(4-fluorophenyl)-5-({3-[4-(1,3-thiazol-2-ylcarbonyl)piperazin-1-yl]azetidin-1-yl}carbonyl)-1H-indole hydrochloride

Guidance literature:: Multi-step reaction with 4 steps

1: trans-N,N'-dimethylcyclohexane-1,2-diamine; tripotassium phosphate "n" hydrate; copper(l) iodide / toluene / 16 h / 85 °C / Inert atmosphere

2: lithium hydroxide / tetrahydrofuran; water / 18 h / 55 °C / Inert atmosphere

3: triethylamine; HATU / dichloromethane / 72 h / 20 °C / Inert atmosphere

4: hydrogenchloride / dichloromethane; water / 1 h / Inert atmosphere

With hydrogenchloride; copper(l) iodide; tripotassium phosphate "n" hydrate; trans-N,N'-dimethylcyclohexane-1,2-diamine; triethylamine; HATU; lithium hydroxide; In tetrahydrofuran; dichloromethane; water; toluene;