10H-[1,2,3]Triazolo[5,1-c][1,4]benzodiazepine

Base Information

• Chemical Name: 10H-[1,2,3]Triazolo[5,1-c][1,4]benzodiazepine
• CAS No.: 127933-84-0
• Molecular Formula: C₁₀H₈N₄
• Molecular Weight: 184.2
• Mol file: 127933-84-0.mol

Synonyms:NSC 653544

Chemical Property of 10H-[1,2,3]Triazolo[5,1-c][1,4]benzodiazepine

Chemical Property:

• Vapor Pressure: 2.85E-07mmHg at 25°C
• Boiling Point: 420.3°Cat760mmHg
• Flash Point: 208°C
• Density: 1.38g/cm³

Purity/Quality:

85.0-99.8% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 10H-[1,2,3]Triazolo[5,1-c][1,4]benzodiazepine

There total 10 articles about 10H-[1,2,3]Triazolo[5,1-c][1,4]benzodiazepine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 36.0%

1-(2-aminobenzyl)-1,2,3-triazole-5-carbaldehyde diethylacetal (127933-83-9) → 5H-1,2,3-triazolo<5,1-c><1,4>benzodiazepine (127933-84-0)

Guidance literature:

at 180 ℃; for 0.0833333h;

DOI:10.1002/jhet.5570260618

Reference yield: 25.0%

10,11-dihydro-5H-1,2,3-triazolo<5,1-c><1,4>benzodiazepine (127933-85-1) → 5H-1,2,3-triazolo<5,1-c><1,4>benzodiazepine (127933-84-0)

Guidance literature:

palladium on activated charcoal; at 170 ℃; for 5h; under 0.1 Torr;

DOI:10.1002/jhet.5570260618

Reference yield:

1-(azidomethyl)-2-nitrobenzene (95668-86-3) → 5H-1,2,3-triazolo<5,1-c><1,4>benzodiazepine (127933-84-0)

Guidance literature:

Multi-step reaction with 3 steps

1: 40 percent / benzene / 30 h / Heating

2: 70 percent / H₂ / palladium on barium sulfate / ethyl acetate / 24 h / 1810.02 Torr

3: 36 percent / 0.08 h / 180 °C

With hydrogen; Pd-BaSO₄; In ethyl acetate; benzene;

DOI:10.1002/jhet.5570260618

upstream raw materials:

10,11-dihydro-5H-1,2,3-triazolo<5,1-c><1,4>benzodiazepine

1-(2-aminobenzyl)-1,2,3-triazole-5-carbaldehyde diethylacetal

1-(azidomethyl)-2-nitrobenzene

10,11-dihydro-5H-1,2,3-triazolo<5,1-c><1,4>benzodiazepin-11-one