95668-86-3

Basic information

• Product Name: Benzene, 1-(azidomethyl)-2-nitro-
• CAS NO: 95668-86-3
• Molecular Formula: C7H6N4O2
• Molecular Weight: 178.15
• Mol File: 95668-86-3.mol
• Article Data: 26

Chemical Properties

• CAS DataBase Reference: Benzene, 1-(azidomethyl)-2-nitro-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzene, 1-(azidomethyl)-2-nitro-(95668-86-3)
• EPA Substance Registry System: Benzene, 1-(azidomethyl)-2-nitro-(95668-86-3)

Safety Data

• Hazardous Substances Data: 95668-86-3(Hazardous Substances Data)

Upstream product

• 612-23-7 2-nitrobenzyl chloride 
• 163915-96-6 (2-nitrophenyl)methyl methanesulfonate 
• 552-89-6 2-nitro-benzaldehyde 
• 100-14-1 4-nitrobenzyl chloride 
• 619-73-8 4-nitrobenzyl chloride 
• 612-25-9 2-Nitrobenzyl alcohol 
• 3958-60-9 2-nitrophenylmethyl bromide 

Downstream Products

• 95668-87-4 ethyl 1-(2-nitrobenzyl)-5-tetrazolecarboxylate 
• 127933-90-8 diethyl 1-(2-nitrobenzyl)-1,2,3-triazole-4,5-dicarboxylate 
• 1280497-50-8 5-(4-fluorophenyl)-1-(2-nitrobenzyl)-1H-1,2,3-triazole 
• 36567-87-0 2-(2'-nitrophenyl)-4(3H)-quinazolinone 
• 95668-88-5 ethyl 1-(2-aminobenzyl)-5-tetrazolecarboxylate 
• 127933-91-9 diethyl 1-(2-aminobenzyl)-1,2,3-triazole-4,5-dicarboxylate 
• 127933-83-9 1-(2-aminobenzyl)-1,2,3-triazole-5-carbaldehyde diethylacetal 
• 127933-87-3 ethyl 1-(2-aminobenzyl)-1,2,3-triazole-5-carboxylate 
• 127933-82-8 1-(2-nitrobenzyl)-1,2,3-triazole-4-carbaldehyde 
• 127933-81-7 1-(2-nitrobenzyl)-1,2,3-triazole-5-carbaldehyde 
• 127933-84-0 5H-1,2,3-triazolo<5,1-c><1,4>benzodiazepine 
• 63777-96-8 1-(2-nitrobenzyl)-1H-1,2,3-triazole 
• 126800-30-4 ethyl 1-(2-nitrobenzyl)-1H-1,2,3-triazole-4-carboxylate 
• 127933-86-2 ethyl 1-(2-nitrobenzyl)-1,2,3-triazole-5-carboxylate 

Relevant articles and documents

Dipolar HCP materials as alternatives to DMF solvent for azide-based synthesis

Hypercrosslinked polymers HCP-DMF and HCP-DMF-SO3H containing abundant and flexible DMF moieties were designed and synthesized. Benefitting from the solvation microenvironment provided by the pseudo-DMF moities, the polar HCPs manifested outstanding performances in the conversions of NaN3 to benzylic azides and 1,2,3-triazoles in EtOH (95%), respectively, avoiding the use of risky DMF and improving the separation processes of the products.

Design, synthesis, and evaluation of metronidazole-1,2,3-triazole derivatives as potent urease inhibitors

A new series of metronidazole-1,2,3-triazole derivatives 6a–o was synthesized and evaluated as Helicobacter pylori urease inhibitors. All the synthesized compounds were more potent than standard inhibitor thiourea against urease. Among the synthesized compounds, compound 6f (IC50 = 1.975 ± 0.25?μM) with inhibitory activity around 11-fols more than thiourea (IC50 = 22.00 ± 0.14?μM) was the most potent compound. Kinetic study of this compound revealed that compound 6f inhibited urease in an uncompetitive mode. Based on molecular modeling study, compound 6f pointed toward the bi-nickel center and stabilized by H-bond and T-shape π–π hydrophobic interactions with the critical residues His492 and Asp633. Moreover, it anchored to the helix-turn-helix motif in the active site cavity through interaction with His593 and Arg609. Consequently, it proposed that compound 6f through stabilization of active site flap inhibited urease activity.

Synthesis of 1,2,3,triazole modified analogues of hydrochlorothiazide via click chemistry approach and in-vitro α-glucosidase enzyme inhibition studies

The current study was aimed to discover potent inhibitors of α-glucosidase enzyme. A 25 membered library of new 1,2,3-triazole derivatives of hydrochlorothiazide (1) (HCTZ, a diuretic drug also being used for the treatment of high blood pressure) was synt