3,4-Difluoro-N,N-dimethylaniline

Base Information

• Chemical Name: 3,4-Difluoro-N,N-dimethylaniline
• CAS No.: 933585-36-5
• Molecular Formula: C₈H₉F₂N
• Molecular Weight: 157.163
• DSSTox Substance ID: DTXSID90592828
• Wikidata: Q82487154
• Mol file: 933585-36-5.mol

Synonyms:3,4-DIFLUORO-N,N-DIMETHYLANILINE;933585-36-5;SCHEMBL7692723;DTXSID90592828;(3,4-Difluorophenyl)dimethylamine;MFCD04116331;SB75881;G11379

Chemical Property of 3,4-Difluoro-N,N-dimethylaniline

Chemical Property:

• PSA: 3.24000
• LogP: 2.03080
• Storage Temp.: 2-8°C
• XLogP3: 2.4
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 1
• Exact Mass: 157.07030562
• Heavy Atom Count: 11
• Complexity: 127

Purity/Quality:

98%Min ^*data from raw suppliers

3,4-Difluoro-N,N-dimethylaniline 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CN(C)C1=CC(=C(C=C1)F)F

Technology Process of 3,4-Difluoro-N,N-dimethylaniline

There total 1 articles about 3,4-Difluoro-N,N-dimethylaniline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

methyl iodide (74-88-4) + 3,4-difluoroaniline (3863-11-4) → 3,4-difluoro-N,N-dimethylaniline (933585-36-5)

Guidance literature:

With sodium hydride; In N,N-dimethyl-formamide; mineral oil; at 0 - 25 ℃; for 12h; Inert atmosphere; Sealed tube;

DOI:10.1021/acs.orglett.9b03789

upstream raw materials:

methyl iodide

3,4-difluoroaniline

Refernces