Neomenthylamine

Base Information

• Chemical Name: Neomenthylamine
• CAS No.: 7231-40-5
• Molecular Formula: C₁₀H₂₁N
• Molecular Weight: 155.283
• Mol file: 7231-40-5.mol

Synonyms:Neomenthylamine;(1S,2S,5R)-2-Isopropyl-5-methylcyclohexane-1-amine

Chemical Property of Neomenthylamine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Neomenthylamine

There total 34 articles about Neomenthylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

DL-neomenthol (490-99-3,491-01-0,491-02-1,1490-04-6,2216-51-5,2216-52-6,3623-51-6,3623-52-7,3623-53-8,15356-60-2,15356-70-4,20747-49-3,20752-33-4,20752-34-5,23283-97-8,64282-88-8,89-78-1) → rac-menthylamine (2216-54-8,4894-99-9,7231-40-5,16934-77-3,20706-69-8,20706-70-1,21411-81-4,23399-21-5,51743-63-6,66609-74-3,85549-06-0,787534-09-2)

Guidance literature:

DL-neomenthol; With 1-methyl-1H-imidazole; methanesulfonyl chloride; triethylamine; In toluene; at 20 ℃; for 2h;

With sodium azide; In N,N-dimethyl-formamide; at 40 ℃; for 48h;

With hydrogen; nickel; In tetrahydrofuran; at 20 ℃; for 72h;

DOI:10.1002/ejoc.201301566

Reference yield: 98.0%

2‐azido‐1‐isopropyl‐4‐methylcyclohexane (898543-45-8,898543-46-9) → rac-menthylamine (2216-54-8,4894-99-9,7231-40-5,16934-77-3,20706-69-8,20706-70-1,21411-81-4,23399-21-5,51743-63-6,66609-74-3,85549-06-0,787534-09-2)

Guidance literature:

With hydrogen; In tetrahydrofuran; at 20 ℃; for 72h;

DOI:10.1055/s-0030-1258295

Reference yield: 82.0%

(S)-N-[(1S,2S,5R)-2-isopropyl-5-methylcyclohexyl]-2-methylpropane-2-sulfinamide → (+)-(1R,3S,4S)-neomenthylamine (7231-40-5,787534-09-2)

Guidance literature:

With hydrogenchloride; In methanol; at 20 ℃; for 2h;

DOI:10.1002/ejoc.201801323

upstream raw materials:

ammonium formate

(1R,4R)-(+)-isomenthone

(2R,5S)-menthone

dl-neomenthylamine

Downstream raw materials:

N-((1R)-neomenthyl)-formamide

p-menthane-4-ol

(+)-neomenthylamine

N-((1R)-neomenthyl)-glycine ethyl ester