(R)-2-(3-(methoxycarbonyl)pyrrolidin-1-yl)acetic acid

Base Information

• Chemical Name: (R)-2-(3-(methoxycarbonyl)pyrrolidin-1-yl)acetic acid
• CAS No.: 942189-34-6
• Molecular Formula: C8H13NO4
• Molecular Weight: 187.19312
• Hs Code.: 2933990090
• Mol file: 942189-34-6.mol

Synonyms:(R)-2-(3-(methoxycarbonyl)pyrrolidin-1-yl)acetic acid;(R)-1-Carboxymethyl-pyrrolidine-3-carboxylic acid methyl ester

Chemical Property of (R)-2-(3-(methoxycarbonyl)pyrrolidin-1-yl)acetic acid

Chemical Property:

• PSA: 66.84000
• LogP: -0.49620
• Storage Temp.: 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

(R)-1-Carboxymethyl-pyrrolidine-3-carboxylicacidmethylester 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
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MSDS Files:

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Technology Process of (R)-2-(3-(methoxycarbonyl)pyrrolidin-1-yl)acetic acid

There total 1 articles about (R)-2-(3-(methoxycarbonyl)pyrrolidin-1-yl)acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

R-1-tert-butoxycarbonylmethyl-pyrrolidine-3-carboxylic acid methyl ester (942189-33-5) → 1-carboxymethyl-pyrrolidine-3-carboxylic acid methyl ester (942189-34-6)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; for 2h;

Reference yield:

1-carboxymethyl-pyrrolidine-3-carboxylic acid methyl ester (942189-34-6) + 2-(4-piperazin-1-yl-phenyl)-pyrimidine (940903-37-7) → 1-{2-oxo-2-[4-(4-pyrimidin-2-yl-phenyl)-piperazin-1-yl]-ethyl}-pyrrolidine-3-carboxylic acid methyl ester (942189-36-8)

Guidance literature:

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In N,N-dimethyl-formamide; for 24h;

Reference yield:

1-carboxymethyl-pyrrolidine-3-carboxylic acid methyl ester (942189-34-6) + 2-(4-piperazin-1-yl-phenyl)-pyrimidine hydrochloride (1056624-11-3,1427195-19-4) → 1-{2-oxo-2-[4-(4-pyrimidin-2-yl-phenyl)-piperazin-1-yl]-ethyl}-pyrrolidine-3-carboxylic acid methyl ester (942189-36-8)

Guidance literature:

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In N,N-dimethyl-formamide; for 24h;

upstream raw materials:

R-1-tert-butoxycarbonylmethyl-pyrrolidine-3-carboxylic acid methyl ester

Downstream raw materials:

1-{2-oxo-2-[4-(4-pyrimidin-2-yl-phenyl)-piperazin-1-yl]-ethyl}-pyrrolidine-3-carboxylic acid methyl ester

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