4-(2,3-Dichlorophenyl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylic acid 3-methyl 5-(1-methylethyl) ester

Base Information

Chemical Name:4-(2,3-Dichlorophenyl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylic acid 3-methyl 5-(1-methylethyl) ester
CAS No.:74073-24-8
Molecular Formula:C19H21Cl2NO4
Molecular Weight:398.28
Hs Code.:
Mol file:74073-24-8.mol

Synonyms:4-(2,3-Dichlorophenyl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylic acid 3-methyl 5-(1-methylethyl) ester;NPK-1961

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 4-(2,3-Dichlorophenyl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylic acid 3-methyl 5-(1-methylethyl) ester

Chemical Property:

PSA：64.63000
LogP:4.68160

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

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Technology Process of 4-(2,3-Dichlorophenyl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylic acid 3-methyl 5-(1-methylethyl) ester

There total 7 articles about 4-(2,3-Dichlorophenyl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylic acid 3-methyl 5-(1-methylethyl) ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 144732-91-2
(S)-isopropyl 4-acetoxymethyl-4-(2,3-dichlorophenyl)-1,4-dihydro-5-methoxycarbonyl-6-methyl-3-pyridinecarboxylate

: 74073-24-8
3-isopropyl 5-methyl (4S)-4-(2,3-dichlorophenyl)-1,4-dihydro-2,6-dimethylpyridine-3,5-dicarboxylate

Guidance literature:: With hydrogen; palladium on activated charcoal; In methanol; for 2h;
DOI:10.1248/cpb.45.869

Reference yield:

: 134969-44-1
isopropyl 4-bromo-3-oxobutanoate

: 74073-24-8
3-isopropyl 5-methyl (4S)-4-(2,3-dichlorophenyl)-1,4-dihydro-2,6-dimethylpyridine-3,5-dicarboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: 48 percent / AcOH / 18 h / 90 °C

2: 43 percent / propan-2-ol / 18 h / Heating

4: 72 percent / H₂ / Pd/C / methanol / 2 h

With hydrogen; acetic acid; palladium on activated charcoal; In methanol; isopropyl alcohol;
DOI:10.1248/cpb.45.869

Reference yield:

: 144686-68-0
isopropyl 4-acetoxymethyl-4-(2,3-dichlorophenyl)-1,4-dihydro-5-methoxycarbonyl-6-methyl-3-pyridinecarboxylate

: 74073-24-8
3-isopropyl 5-methyl (4S)-4-(2,3-dichlorophenyl)-1,4-dihydro-2,6-dimethylpyridine-3,5-dicarboxylate

Guidance literature:: Multi-step reaction with 2 steps

2: 72 percent / H₂ / Pd/C / methanol / 2 h

With hydrogen; palladium on activated charcoal; In methanol;
DOI:10.1248/cpb.45.869