144732-91-2

Basic information

• Product Name: (S)-isopropyl 4-acetoxymethyl-4-(2,3-dichlorophenyl)-1,4-dihydro-5-methoxycarbonyl-6-methyl-3-pyridinecarboxylate
• Synonyms: (S)-isopropyl 4-acetoxymethyl-4-(2,3-dichlorophenyl)-1,4-dihydro-5-methoxycarbonyl-6-methyl-3-pyridinecarboxylate
• CAS NO: 144732-91-2
• Molecular Weight: 456.323
• Mol File: 144732-91-2.mol

Chemical Properties

• CAS DataBase Reference: (S)-isopropyl 4-acetoxymethyl-4-(2,3-dichlorophenyl)-1,4-dihydro-5-methoxycarbonyl-6-methyl-3-pyridinecarboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-isopropyl 4-acetoxymethyl-4-(2,3-dichlorophenyl)-1,4-dihydro-5-methoxycarbonyl-6-methyl-3-pyridinecarboxylate(144732-91-2)
• EPA Substance Registry System: (S)-isopropyl 4-acetoxymethyl-4-(2,3-dichlorophenyl)-1,4-dihydro-5-methoxycarbonyl-6-methyl-3-pyridinecarboxylate(144732-91-2)

Safety Data

• Hazardous Substances Data: 144732-91-2(Hazardous Substances Data)

Upstream product

• 144686-68-0 isopropyl 4-acetoxymethyl-4-(2,3-dichlorophenyl)-1,4-dihydro-5-methoxycarbonyl-6-methyl-3-pyridinecarboxylate 
• 144686-67-9 isopropyl 4-acetoxyacetoacetate 
• 134969-44-1 isopropyl 4-bromo-3-oxobutanoate 

Downstream Products

• 125729-31-9 (S)-isopropyl 1,4-dihydro-2-carbamoyloxymethyl-4-(2,3-dichlorophenyl)-5-methoxycarbonyl-6-methyl-3-pyridinecarboxylate 
• 144686-70-4 (S)-isopropyl 4-(2,3-dichlorophenyl)-1,4-dihydro-2-hydroxymethyl-3-methoxycarbonyl-6-methyl-5-pyridinecarboxylate 
• 74073-24-8 3-isopropyl 5-methyl (4S)-4-(2,3-dichlorophenyl)-1,4-dihydro-2,6-dimethylpyridine-3,5-dicarboxylate 

Relevant articles and documents

Enzymatic Synthesis of Optically Active 2-Carbamoyloxymethyl-1,4-dihydropyridines, (R)-(+)- and (S)-(-)-NB 818

Racemic dihydropyridines were resolved by enzyme-catalyzed hydrolysis in an organic solvent saturated with water.The chiral derivatives obtained were converted to (S)- and (R)-NB 818.

Asymmetric synthesis of (R)-nilvadipine and (S)-NB 818 via regioselective bromination of chiral 1,4-dihydropyridines as a key step and enzymatic resolution of racemic 2-hydroxymethyl-1,4-dihydropyridine derivatives

Optically active 2-hydroxymethyl-1,4,dihydropyridines were obtained by lipase-catalyzed hydrolysis or transesterification of racemic materials. Chiral NB 818 and nilvadipine have been synthesized from chiral 2- hydroxymethyl-1,4-dihydropyridine. On the ot