[(3S)-1-methylpyrrolidin-3-yl]methanamine

Base Information

• Chemical Name: [(3S)-1-methylpyrrolidin-3-yl]methanamine
• CAS No.: 1419075-98-1
• Molecular Formula: C₆H₁₄N₂
• Molecular Weight: 114.191
• Mol file: 1419075-98-1.mol

Synonyms:[(3S)-1-methylpyrrolidin-3-yl]methanamine;(S)-(1-Methylpyrrolidin-3-yl)methanamine

Chemical Property of [(3S)-1-methylpyrrolidin-3-yl]methanamine

Chemical Property:

• PSA: 29.26000
• LogP: 0.53500
• Storage Temp.: 2-8°C(protect from light)

Purity/Quality:

97% ^*data from raw suppliers

[(3S)-1-methylpyrrolidin-3-yl]methanamine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of [(3S)-1-methylpyrrolidin-3-yl]methanamine

There total 2 articles about [(3S)-1-methylpyrrolidin-3-yl]methanamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

tert-butyl (R)-3-(aminomethyl)pyrrolidine-1-carboxylate (199174-29-3) → (R)-(1-methylpyrrolidin-3-yl)methanamine (1207541-15-8,1419075-98-1)

Guidance literature:

tert-butyl (R)-3-(aminomethyl)pyrrolidine-1-carboxylate; With lithium aluminium tetrahydride; In tetrahydrofuran; at 20 ℃;

With water; sodium hydroxide; In tetrahydrofuran; for 0.166667h;

Reference yield:

→ N-methyl-3-aminomethyl pyrrolidine (13005-11-3,1419075-98-1)

Guidance literature:

entspr. Pyrrolidon I, LiAlH4;

Reference yield: 52.0%

3-chloro-5-ethyl-6-hydroxy-2-methoxybenzoic acid (101536-78-1) + N-methyl-3-aminomethyl pyrrolidine (13005-11-3,1419075-98-1) → 3-chloro-5-ethyl-6-hydroxy-2-methoxy-N-((1-methylpyrrolidin-3-yl)methyl)benzamide

Guidance literature:

3-chloro-5-ethyl-6-hydroxy-2-methoxybenzoic acid; With 1,1'-carbonyldiimidazole; In tetrahydrofuran; at 20 ℃; for 2h; Inert atmosphere;

N-methyl-3-aminomethyl pyrrolidine; In tetrahydrofuran; at 20 ℃; Inert atmosphere;

DOI:10.1021/acs.jmedchem.1c01353

upstream raw materials:

tert-butyl (R)-3-(aminomethyl)pyrrolidine-1-carboxylate

Downstream raw materials:

C₁₈H₂₃FN₂O₃