estradiol 17-dihydrotrigonelline

Base Information

• Chemical Name: estradiol 17-dihydrotrigonelline
• CAS No.: 103562-82-9
• Molecular Formula: C₂₅H₃₁NO₃
• Molecular Weight: 393.526
• Mol file: 103562-82-9.mol

Synonyms:E2-CDS

Chemical Property of estradiol 17-dihydrotrigonelline

Chemical Property:

• Vapor Pressure: 6.46E-13mmHg at 25°C
• Boiling Point: 554.8°Cat760mmHg
• Flash Point: 289.3°C
• PSA: 49.77000
• Density: 1.22g/cm³
• LogP: 4.83110

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of estradiol 17-dihydrotrigonelline

There total 5 articles about estradiol 17-dihydrotrigonelline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

1-methyl-3-<<<3-hydroxyestra-1,3,5(10)-trien-17β-yl>oxy>carbonyl>pyridinium iodide (106146-63-8) → 3-hydroxy-17β-<<(1-methyl-1,4-dihydropyridin-3-yl)carbonyl>oxy>estra-1,3,5(10)-triene (103562-82-9)

Guidance literature:

With sodium dithionite; sodium hydrogencarbonate; In water; tert-butyl alcohol; at 0 ℃; for 1h;

DOI:10.1021/jm00396a038

Reference yield: 64.0%

→ 3-hydroxy-17β-<<(1-methyl-1,4-dihydropyridin-3-yl)carbonyl>oxy>estra-1,3,5(10)-triene (103562-82-9)

Guidance literature:

Reference yield:

estradiol (50-28-2) → 3-hydroxy-17β-<<(1-methyl-1,4-dihydropyridin-3-yl)carbonyl>oxy>estra-1,3,5(10)-triene (103562-82-9)

Guidance literature:

Multi-step reaction with 4 steps

1: 90 percent / pyridine / 1 h / Heating

2: 94 percent / KHCO₃ / methanol; H₂O / Ambient temperature

3: 83 percent / acetone / Heating

4: 64 percent / NaHCO₃, Na₂S₂O₄ / 2-methyl-propan-2-ol; H₂O / 1 h / 0 °C

With sodium dithionite; sodium hydrogencarbonate; potassium hydrogencarbonate; In pyridine; methanol; water; acetone; tert-butyl alcohol;

DOI:10.1021/jm00396a038

upstream raw materials:

1-methyl-3-<<<3-hydroxyestra-1,3,5(10)-trien-17β-yl>oxy>carbonyl>pyridinium iodide

estradiol

3-hydroxy-17β-<(3-pyridinylcarbonyl)oxy>estra-1,3,5(10)-triene

3,17β-Bis[(3-pyridinylcarbonyl)oxy]-estra-1,3,5(10)-triene

Refernces

• 1、 Brewster,Estes,Loftsson,Perchalski,Derendorf,Mullersman,Bodor. "Improved delivery through biological membranes XXXI: Solubilization and stabilization of an estradiol chemical delivery system by modified β-cyclodextrins". . p. 981 - 985. Retrieved 1988.
• 2、 -. "Method for treating male sexual dysfunction". . . Retrieved 2008/06/13.
• 3、 Brewster,Estes,Bodor. "Improved delivery through biological membranes. 32. Synthesis and biological activity of brain-targeted delivery systems for various estradiol derivatives". . p. 244 - 249. Retrieved 2007/10/02.