(R)-3-(BENZYLOXYCARBONYLAMINO)-2-PHENYLPROPANOIC ACID

Base Information

Chemical Name:(R)-3-(BENZYLOXYCARBONYLAMINO)-2-PHENYLPROPANOIC ACID
CAS No.:1040-59-1
Molecular Formula:C17H17NO4
Molecular Weight:0
Hs Code.:
Mol file:1040-59-1.mol

Synonyms:(R)-3-(BENZYLOXYCARBONYLAMINO)-2-PHENYLPROPANOIC ACID;(R)-CBZ-BETA2-PHENYLALANINE

Suppliers and Price of (R)-3-(BENZYLOXYCARBONYLAMINO)-2-PHENYLPROPANOIC ACID

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 8 raw suppliers

Chemical Property of (R)-3-(BENZYLOXYCARBONYLAMINO)-2-PHENYLPROPANOIC ACID

Chemical Property:

Melting Point:95 - 97 °C (light petroleum)
PSA：75.63000
LogP:3.17210

Purity/Quality:: 98%,99%, ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of (R)-3-(BENZYLOXYCARBONYLAMINO)-2-PHENYLPROPANOIC ACID

There total 6 articles about (R)-3-(BENZYLOXYCARBONYLAMINO)-2-PHENYLPROPANOIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 161583-20-6
[(R)-3-((4S,5R)-4-Methyl-2-oxo-5-phenyl-oxazolidin-3-yl)-3-oxo-2-phenyl-propyl]-carbamic acid benzyl ester

: 1040-59-1
(R)-3-Benzyloxycarbonylamino-2-phenyl-propionic acid

Guidance literature:: With lithium hydroxide; dihydrogen peroxide; In tetrahydrofuran; at 0 ℃; for 0.5h;
DOI:10.1039/a706163c

Reference yield:

: 141022-85-7
(4S,5R)-4-methyl-5-phenyl-3-phenylacetyloxazolidin-2-one

: 1040-59-1
(R)-3-Benzyloxycarbonylamino-2-phenyl-propionic acid

Guidance literature:: Multi-step reaction with 4 steps

1: 67 percent / LiHMDS / tetrahydrofuran / 1.) -72 deg C, 30 min, 2.) -72 to -20 deg C, 2 h

2: 98 percent / TFA / 1 h / Ambient temperature

3: 59 percent / Et₃N, diphenylphosphoryl azide / toluene / 1.) 20 deg C, 1 h, 2.) reflux, 1 h

4: 65 percent / aq. LiOH, H₂O₂ / tetrahydrofuran / 0.5 h / 0 °C

With lithium hydroxide; diphenylphosphoranyl azide; dihydrogen peroxide; triethylamine; trifluoroacetic acid; lithium hexamethyldisilazane; In tetrahydrofuran; toluene;
DOI:10.1039/a706163c

Reference yield:

: 67799-92-2
benzyloxycarbonylaminomethyl acetate

: 1040-59-1
(R)-3-Benzyloxycarbonylamino-2-phenyl-propionic acid

Guidance literature:: Multi-step reaction with 2 steps

2: 65 percent / aq. LiOH, H₂O₂ / tetrahydrofuran / 0.5 h / 0 °C

With lithium hydroxide; dihydrogen peroxide; In tetrahydrofuran;
DOI:10.1039/a706163c