N-Formyl N,N-Didesmethyl Sibutramine

Base Information

Chemical Name:N-Formyl N,N-Didesmethyl Sibutramine
CAS No.:84467-85-6
Molecular Formula:C16H22ClNO
Molecular Weight:279.80498
Hs Code.:29242990
UNII:P623ZR3N4K
DSSTox Substance ID:DTXSID80517661
Nikkaji Number:J1.347.042A
Wikidata:Q27286273
Mol file:84467-85-6.mol

Synonyms:N-Formyl N,N-Didesmethyl Sibutramine;84467-85-6;N-[1-[1-(4-chlorophenyl)cyclobutyl]-3-methylbutyl]formamide;N-Formyl-desmethyl-sibutramine;P623ZR3N4K;N-{1-[1-(4-Chlorophenyl)cyclobutyl]-3-methylbutyl}formamide;Formamide, N-(1-(1-(4-chlorophenyl)cyclobutyl)-3-methylbutyl)-;Formamide, N-[1-[1-(4-chlorophenyl)cyclobutyl]-3-methylbutyl]-;SCHEMBL2644;UNII-P623ZR3N4K;DTXSID80517661;FT-0668823;Q27286273;Formamide,N-[1-[1-(4-chlorophenyl)cyclobutyl]-3-methylbutyl]-

Suppliers and Price of N-Formyl N,N-Didesmethyl Sibutramine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Usbiological
N-Formyl N,N-Didesmethyl Sibutramine|
5mg
$ 460.00

TRC
N-FormylN,N-DidesmethylSibutramine
50mg
$ 990.00

American Custom Chemicals Corporation
N-FORMYL N,N-DIDESMETHYL SIBUTRAMINE 95.00%
50MG
$ 1732.50

American Custom Chemicals Corporation
N-FORMYL N,N-DIDESMETHYL SIBUTRAMINE 95.00%
5MG
$ 756.25

Total 11 raw suppliers

Chemical Property of N-Formyl N,N-Didesmethyl Sibutramine

Chemical Property:

Vapor Pressure:1.88E-07mmHg at 25°C
Melting Point:110-111°C
Boiling Point:425.7°C at 760 mmHg
PKA:15.95±0.23(Predicted)
Flash Point:211.2°C
PSA：32.59000
Density:1.102g/cm³
LogP:4.76270
Storage Temp.:-20°C Freezer
Solubility.:Chloroform (Slightly), Methanol (Slightly)
XLogP3:4.7
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:1
Rotatable Bond Count:5
Exact Mass:279.1389920
Heavy Atom Count:19
Complexity:293

Purity/Quality:

99.90% ^*data from raw suppliers

N-Formyl N,N-Didesmethyl Sibutramine| ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(C)CC(C1(CCC1)C2=CC=C(C=C2)Cl)NC=O
Uses An intermediate of a Sibutramine metabolite, a serotonin and noradrenaline reuptake inhibitor (SNR). Decreases calorie intake and increases energy expenditure.

Technology Process of N-Formyl N,N-Didesmethyl Sibutramine

There total 7 articles about N-Formyl N,N-Didesmethyl Sibutramine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

: 107-31-3
Methyl formate

: 106650-56-0,84467-54-9
didesmethylsibutramine

: 84467-85-6
N-{1-[1-(4-chlorophenylcyclobutyl)]-3-methylbuty}formamide

Guidance literature:: for 16h; Heating;
DOI:10.1039/p19960002583

Reference yield: 39.0%

: 77287-34-4,77287-35-5,60100-09-6
formamide

: 186521-85-7
1-[1-(4-chloro-phenyl)cyclobutyl]-3-methyl-butan-1-one

: 84467-85-6
N-{1-[1-(4-chlorophenylcyclobutyl)]-3-methylbuty}formamide

Guidance literature:: In formic acid; at 160 - 180 ℃; for 24.5h;
DOI:10.1021/op980093t

Reference yield:

: 140-53-4
p-chlorobenzyl cyanide

: 84467-85-6
N-{1-[1-(4-chlorophenylcyclobutyl)]-3-methylbuty}formamide

Guidance literature:: Multi-step reaction with 3 steps

1: 74 percent / KOH / diethyl ether; dimethylsulfoxide / 1 h / 20 - 25 °C

3: 30 percent / HCO₂H / 17 h / 180 °C

With potassium hydroxide; formic acid; In diethyl ether; dimethyl sulfoxide;
DOI:10.1039/p19960002583