2-chloro-4-fluoro-3-iodopyridine

Base Information

• Chemical Name: 2-chloro-4-fluoro-3-iodopyridine
• CAS No.: 1271477-28-1
• Molecular Formula: C5H2ClFIN
• Molecular Weight: 257.43
• Hs Code.: 2933399090
• Mol file: 1271477-28-1.mol

Synonyms:2-chloro-4-fluoro-3-iodopyridine

Chemical Property of 2-chloro-4-fluoro-3-iodopyridine

Chemical Property:

• Boiling Point: 257.7±35.0 °C(Predicted)
• PKA: 0.35±0.10(Predicted)
• PSA: 12.89000
• Density: 2.129±0.06 g/cm3(Predicted)
• LogP: 2.47870

Purity/Quality:

97% ^*data from raw suppliers

2-chloro-4-fluoro-3-iodopyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-chloro-4-fluoro-3-iodopyridine

There total 1 articles about 2-chloro-4-fluoro-3-iodopyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

2-chloro-4-fluoropyridine (34941-91-8) → 2-chloro-4-fluoro-3-iodopyridine (1271477-28-1)

Guidance literature:

2-chloro-4-fluoropyridine; With lithium diisopropyl amide; In tetrahydrofuran; at -78 ℃; for 0.5h;

With iodine; In tetrahydrofuran; at -78 ℃; for 0.5h;

Reference yield: 78.0%

2-chloro-4-fluoro-3-iodopyridine (1271477-28-1) + phenylacetylene (536-74-3) → 7-chloro-2-phenylthieno[2,3-c]pyridine

Guidance literature:

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; potassium ethyl xanthogenate; triethylamine; In dimethyl sulfoxide; at 35 - 90 ℃; for 22h; Schlenk technique; Inert atmosphere;

DOI:10.1039/C6OB02351G

Reference yield:

2-chloro-4-fluoro-3-iodopyridine (1271477-28-1) → 6-chloro-4-fluoropyridine-3-carbaldehyde (1060809-20-2)

Guidance literature:

Multi-step reaction with 2 steps

1.1: lithium diisopropyl amide / tetrahydrofuran / 2.75 h / -20 °C

2.1: isopropylmagnesium chloride / tetrahydrofuran / 0.5 h / -20 °C

2.2: 0.5 h

With isopropylmagnesium chloride; lithium diisopropyl amide; In tetrahydrofuran;

upstream raw materials:

2-chloro-4-fluoropyridine

Downstream raw materials:

2-chloro-4-fluoro-5-iodopyridine

6-chloro-4-fluoropyridine-3-carbaldehyde