2-chloro-4-fluoro-5-iodopyridine

Base Information

• Chemical Name: 2-chloro-4-fluoro-5-iodopyridine
• CAS No.: 1370534-60-3
• Molecular Formula: C₅H₂ClFIN
• Molecular Weight: 257.433
• Hs Code.: 2933399990
• Mol file: 1370534-60-3.mol

Synonyms:2-chloro-4-fluoro-5-iodopyridine

Chemical Property of 2-chloro-4-fluoro-5-iodopyridine

Chemical Property:

• Boiling Point: 249.8±35.0 °C(Predicted)
• PKA: -0.95±0.10(Predicted)
• PSA: 12.89000
• Density: 2.129±0.06 g/cm3(Predicted)
• LogP: 2.47870
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C

Purity/Quality:

98%,99%, ^*data from raw suppliers

2-chloro-4-fluoro-5-iodopyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-chloro-4-fluoro-5-iodopyridine

There total 2 articles about 2-chloro-4-fluoro-5-iodopyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-chloro-4-fluoro-3-iodopyridine (1271477-28-1) → 2-chloro-4-fluoro-5-iodopyridine (1370534-60-3)

Guidance literature:

With lithium diisopropyl amide; In tetrahydrofuran; at -20 ℃; for 2.75h;

Reference yield:

2-chloro-4-fluoropyridine (34941-91-8) → 2-chloro-4-fluoro-5-iodopyridine (1370534-60-3)

Guidance literature:

Multi-step reaction with 2 steps

1.1: lithium diisopropyl amide / tetrahydrofuran / 0.5 h / -78 °C

1.2: 0.33 h

2.1: lithium diisopropyl amide / tetrahydrofuran / 2.75 h / -20 °C

With lithium diisopropyl amide; In tetrahydrofuran;

Reference yield:

2-chloro-4-fluoro-5-iodopyridine (1370534-60-3) → C21H18F3N5O3

Guidance literature:

Multi-step reaction with 2 steps

1: potassium tert-butylate / toluene / 1 h / 70 °C / Microwave irradiation; Inert atmosphere

2: tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; caesium carbonate / 1,4-dioxane / 1 h / 95 °C / Inert atmosphere

With tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; potassium tert-butylate; caesium carbonate; In 1,4-dioxane; toluene;

upstream raw materials:

2-chloro-4-fluoropyridine

2-chloro-4-fluoro-3-iodopyridine

Downstream raw materials:

6-chloro-4-fluoropyridine-3-carbaldehyde

Refernces