6-chloro-5-fluoro-1H-pyrrolo[2,3-b]pyridine

Base Information

Chemical Name:6-chloro-5-fluoro-1H-pyrrolo[2,3-b]pyridine
CAS No.:1190321-96-0
Molecular Formula:C₇H₄ClFN₂
Molecular Weight:170.574
Hs Code.:
DSSTox Substance ID:DTXSID90696658
Wikidata:Q72451502
Mol file:1190321-96-0.mol

Synonyms:6-CHLORO-5-FLUORO-7-AZAINDOLE;1190321-96-0;6-chloro-5-fluoro-1H-pyrrolo[2,3-b]pyridine;1H-Pyrrolo[2,3-b]pyridine, 6-chloro-5-fluoro-;SCHEMBL9288889;AMY2846;DTXSID90696658;NYXAEXRADNADKD-UHFFFAOYSA-N;MFCD12962829;SB14483;AS-49474;CS-0050220;I10796

Suppliers and Price of 6-chloro-5-fluoro-1H-pyrrolo[2,3-b]pyridine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
6-Chloro-5-fluoro-7-azaindole
10mg
$ 130.00

Crysdot
6-Chloro-5-fluoro-7-azaindole 95+%
1g
$ 719.00

Chemenu
6-Chloro-5-fluoro-7-azaindole 95%+
1g
$ 1280.00

Chemenu
6-Chloro-5-fluoro-7-azaindole 95%+
100mg
$ 298.00

Chemenu
6-Chloro-5-fluoro-7-azaindole 95%+
250mg
$ 638.00

American Custom Chemicals Corporation
6-CHLORO-5-FLUORO-7-AZAINDOLE 95.00%
5MG
$ 497.10

Alichem
6-Chloro-5-fluoro-7-azaindole
1g
$ 690.80

AK Scientific
6-Chloro-5-fluoro-7-azaindole
25mg
$ 252.00

AK Scientific
6-Chloro-5-fluoro-7-azaindole
250mg
$ 860.00

Abosyn
6-chloro-5-fluoro-1H-pyrrolo[2,3-b]pyridine 95%-98%
1g
$ 648.00

Total 18 raw suppliers

Chemical Property of 6-chloro-5-fluoro-1H-pyrrolo[2,3-b]pyridine

Chemical Property:

PKA:12.14±0.40(Predicted)
PSA：28.68000
Density:1.533
LogP:2.35540
Storage Temp.:2-8°C
XLogP3:2.4
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:0
Exact Mass:170.0047040
Heavy Atom Count:11
Complexity:155

Purity/Quality:

99%, ^*data from raw suppliers

6-Chloro-5-fluoro-7-azaindole ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=CNC2=NC(=C(C=C21)F)Cl

Technology Process of 6-chloro-5-fluoro-1H-pyrrolo[2,3-b]pyridine

There total 2 articles about 6-chloro-5-fluoro-1H-pyrrolo[2,3-b]pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 882033-65-0
5-fluoro-1H-pyrrolo[2,3-b]pyridine-7-oxide

: 1190321-96-0
6-chloro-5-fluoro-1H-pyrrolo[2,3-b]pyridine

Guidance literature:: 5-fluoro-1H-pyrrolo[2,3-b]pyridine-7-oxide; With methyl chloroformate; 1,1,1,3,3,3-hexamethyl-disilazane; In tetrahydrofuran; at 5 ℃; for 3h;

With sodium hydroxide; In tetrahydrofuran; at 10 ℃; for 2h;

With hydrogenchloride; In tetrahydrofuran; water; pH=7;

Reference yield:

: 866319-00-8
5-fluoro-1H-pyrrolo[2,3‐b]pyridine

: 1190321-96-0
6-chloro-5-fluoro-1H-pyrrolo[2,3-b]pyridine

Guidance literature:: Multi-step reaction with 2 steps

1.1: 3-chloro-benzenecarboperoxoic acid / diethyl ether / 3.08 h / Inert atmosphere

2.1: 1,1,1,3,3,3-hexamethyl-disilazane; methyl chloroformate / tetrahydrofuran / 3 h / 5 °C

2.2: 2 h / 10 °C

2.3: pH 7

With methyl chloroformate; 3-chloro-benzenecarboperoxoic acid; 1,1,1,3,3,3-hexamethyl-disilazane; In tetrahydrofuran; diethyl ether;