2H-1-BENZOPYRAN-3-AMINE,3,4-DIHYDRO-8-METHOXY-

Base Information

• Chemical Name: 2H-1-BENZOPYRAN-3-AMINE,3,4-DIHYDRO-8-METHOXY-
• CAS No.: 112904-73-1
• Molecular Formula: C₁₀H₁₃NO₂
• Molecular Weight: 179.219
• Hs Code.: 2932999099
• Mol file: 112904-73-1.mol

Synonyms:2H-1-BENZOPYRAN-3-AMINE,3,4-DIHYDRO-8-METHOXY-;(8-methoxy-3,4-dihydro-2H-chromen-3-yl)amine(SALTDATA: FREE);(8-Methoxy-3,4-dihydro-2H-chroMen-3-yl)aMine;(8-Methoxy-3,4-dihydro-2H-chromen-3-yl)amine hydrochloride;3,4-Dihydro-8-methoxy-2H-1-benzopyran-3-amine;(8-methoxychroman-3-yl)amine;8-methoxy-3-chromanamine;8-methoxychroman-3-amine

Chemical Property of 2H-1-BENZOPYRAN-3-AMINE,3,4-DIHYDRO-8-METHOXY-

Chemical Property:

• Melting Point: 203-205℃ (ethanol ethyl ether )
• Boiling Point: 299.3±40.0 °C(Predicted)
• PKA: 7.91±0.20(Predicted)
• PSA: 44.48000
• Density: 1.128±0.06 g/cm3(Predicted)
• LogP: 2.45970

Purity/Quality:

98%min ^*data from raw suppliers

8-Methoxy-3,4-dihydro-2H-1-benzopyran-3-amine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2H-1-BENZOPYRAN-3-AMINE,3,4-DIHYDRO-8-METHOXY-

There total 6 articles about 2H-1-BENZOPYRAN-3-AMINE,3,4-DIHYDRO-8-METHOXY- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

3-acetamido-8-methoxychroman (119284-78-5) → 8-methoxychroman-3-amine (112904-73-1)

Guidance literature:

With hydrogenchloride; 1.) methanol, 90 deg C, 6 h; 2.) r.t., 17 h;

DOI:10.1016/0223-5234(88)90203-6

Reference yield:

8-methoxy-3,4-dihydro-3-nitro-2H-1-benzopyran (137279-47-1) → 8-methoxychroman-3-amine (112904-73-1)

Guidance literature:

With hydrazine hydrate; nickel; In ethanol; at 45 ℃; for 0.5h;

DOI:10.1016/0223-5234(91)90145-D

Reference yield:

3-acetamido-8-methoxy-4-chromanone (119284-77-4) → 8-methoxychroman-3-amine (112904-73-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 87 percent / H₂ / 5percent Pd/C / acetic acid; HClO₄ / 24 h / 30 °C / 2280 Torr

2: 67 percent / 25percent HCl / 1.) methanol, 90 deg C, 6 h; 2.) r.t., 17 h

With hydrogenchloride; hydrogen; palladium on activated charcoal; In perchloric acid; acetic acid;

DOI:10.1016/0223-5234(88)90203-6

upstream raw materials:

8-methoxy-3,4-dihydro-3-nitro-2H-1-benzopyran

3-acetamido-8-methoxychroman

3-acetamido-8-methoxy-4-chromanone

3-amino-8-methoxy-3,4-dihydro-2H-1-benzopyran-4-one hydrochloride

Downstream raw materials:

(-)-8-hydroxy-3,4-dihydro-3-(di-n-propylamino)-2H-1-benzopyran

(+)-8-hydroxy-3,4-dihydro-3-(di-n-propylamino)-2H-1-benzopyran

N,N-di-n-propyl-8-hydroxy-3-chromanamine

Refernces

• 1、 -. "a, ? UNSATURATED AMIDE COMPOUND". Paragraph 0438; 0556. . Retrieved 2018/11/27.
• 2、 Horn, Alan S.,Kaptein, Bernard,Vermue, Niek A.,Vries, Jan B. De,Mulder, Theo B. A.. "Synthesis and dopaminergic activity of a new oxygen isostere of the 2-aminotetralins: N,N-dipropyl-8-hydroxy-3-chromanamine". . p. 325 - 328. Retrieved 2007/10/02.