8-hydroxy-3,4-dihydro-3-(dipropylamino)-2H-1-benzopyran

Base Information

• Chemical Name: 8-hydroxy-3,4-dihydro-3-(dipropylamino)-2H-1-benzopyran
• CAS No.: 112904-74-2
• Molecular Formula: C₁₅H₂₃NO₂
• Molecular Weight: 249.353
• Mol file: 112904-74-2.mol

Synonyms:N,N-Dipropyl-8-hydroxy-3-chromanamine

Chemical Property of 8-hydroxy-3,4-dihydro-3-(dipropylamino)-2H-1-benzopyran

Chemical Property:

• Vapor Pressure: 3.89E-06mmHg at 25°C
• Boiling Point: 374.4°Cat760mmHg
• PKA: 10.16±0.40(Predicted)
• Flash Point: 180.2°C
• PSA: 32.70000
• Density: 1.08g/cm³
• LogP: 2.81770

Purity/Quality:

95+% ^*data from raw suppliers

3-(DIPROPYLAMINO)-3,4-DIHYDRO-2H-1-BENZOPYRAN-8-OL 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 8-hydroxy-3,4-dihydro-3-(dipropylamino)-2H-1-benzopyran

There total 18 articles about 8-hydroxy-3,4-dihydro-3-(dipropylamino)-2H-1-benzopyran which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

8-methoxy-3,4-dihydro-3-(di-n-propylamino)-2H-1-benzopyran (110927-06-5,137279-60-8,137279-61-9) → N,N-di-n-propyl-8-hydroxy-3-chromanamine (112904-74-2,137196-48-6,137279-62-0)

Guidance literature:

With hydrogen bromide; In acetic acid; at 130 - 140 ℃; for 4h;

DOI:10.1016/0223-5234(91)90145-D

Reference yield: 93.0%

(+)-8-methoxy-3,4-dihydro-3-(di-n-propylamino)-2H-1-benzylpyran (110927-06-5,137279-60-8,137279-61-9) → (+)-8-hydroxy-3,4-dihydro-3-(di-n-propylamino)-2H-1-benzopyran (112904-74-2,137196-48-6,137279-62-0)

Guidance literature:

With hydrogen bromide; In acetic acid; at 130 - 140 ℃; for 4h;

DOI:10.1016/0223-5234(91)90145-D

Reference yield: 93.0%

N,N-di-n-propyl-8-methoxy-3-chromanamine hydrochloride (109164-01-4) → N,N-di-n-propyl-8-hydroxy-3-chromanamine (112904-74-2,137196-48-6,137279-62-0)

Guidance literature:

With hydrogen bromide; at 125 - 130 ℃; for 1.08333h;

DOI:10.1016/0223-5234(88)90203-6

upstream raw materials:

8-methoxy-3,4-dihydro-3-(di-n-propylamino)-2H-1-benzopyran

N,N-di-n-propyl-8-methoxy-3-chromanamine hydrochloride

8-methoxy-3-nitro-2H-1-benzopyran

8-methoxychroman-3-amine

Refernces

• 1、 Horn, Alan S.,Kaptein, Bernard,Vermue, Niek A.,Vries, Jan B. De,Mulder, Theo B. A.. "Synthesis and dopaminergic activity of a new oxygen isostere of the 2-aminotetralins: N,N-dipropyl-8-hydroxy-3-chromanamine". . p. 325 - 328. Retrieved 2007/10/02.