DMT-2μ-O-Me-rG(ib) amidite

Base Information

• Chemical Name: DMT-2μ-O-Me-rG(ib) amidite
• CAS No.: 251647-55-9
• Molecular Formula: C45H56N7O9P
• Molecular Weight: 914.008
• Mol file: 251647-55-9.mol

Synonyms:DMT-2μ-O-Me-rG(ib) amidite;5'-O-DMT-N2-isobutyryl-2'-O-methylguanosine 3'-CE phosphoramidite;Guanosine, 5'-O-[bis(4-Methoxyphenyl)phenylMethyl]-2'-O-(2-Methoxyethyl)-N-(2-Methyl-1-oxopropyl)-, 3'-[2-cyanoethyl bis(1-Methylethyl)phosphoraMidite];2'-MOE-G(iBu)-3'-phosphoramidite;5'-O-[Bis(4-methoxyphenyl)phenylmethyl]-2'-O-(2-methoxyethyl)-N-(2-methyl-1-oxopropyl)guanosine 3'-[2-cyanoethyl bis(1-methylethyl)phosphoramidite]

Chemical Property of DMT-2μ-O-Me-rG(ib) amidite

Chemical Property:

• PKA: 9.16±0.20(Predicted)
• PSA: 207.13000
• LogP: 7.40318

Purity/Quality:

97% ^*data from raw suppliers

5''-O-DMT-N2-isobutyryl-2''-O-(2-methoxyethyl)-guanosine3''-CEphosphoramidite ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 5''-O-DMT-N2-isobutyryl-2''-O-(2-methoxyethyl)-guanosine 3''-CE phosphoramidite (CAS# 251647-55-9) is a nucleotide, and a derivative of guanosine, and is used in the stereochemical sythesis of phosphorothioate oligonucleotides.

Technology Process of DMT-2μ-O-Me-rG(ib) amidite

There total 2 articles about DMT-2μ-O-Me-rG(ib) amidite which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

N,N,N',N'-tetraisopropyl 2-cyanoethylphosphorodiamidite (102691-36-1) + 5'-O-(4,4'-dimethoxytriphenylmethyl)-2'-O-(2-methoxyethyl)-N2-isobutyrylguanosine (251647-50-4) → MOE G amidite (251647-55-9)

Guidance literature:

With 1-methyl-1H-imidazole; 1H-tetrazole; In DMF (N,N-dimethyl-formamide); toluene; at 20 ℃; for 5h;

Reference yield:

→ MOE G amidite (251647-55-9)

Guidance literature:

Reference yield:

MOE G amidite (251647-55-9) + N4-benzoyl-3'-O-levulinyl-2'-O-(2-methoxyethyl)-5-methylcytidine → C66H76N9O19P

Guidance literature:

With 1H-tetrazole; In dichloromethane; at 20 - 25 ℃; for 1h; Inert atmosphere;

DOI:10.1002/bkcs.10749

upstream raw materials:

N,N,N',N'-tetraisopropyl 2-cyanoethylphosphorodiamidite

5'-O-(4,4'-dimethoxytriphenylmethyl)-2'-O-(2-methoxyethyl)-N²-isobutyrylguanosine