tert-butyl 4-(chloromethyl)-4-(hydroxymethyl)piperidine-1-carboxylate

Base Information

Chemical Name:tert-butyl 4-(chloromethyl)-4-(hydroxymethyl)piperidine-1-carboxylate
CAS No.:1312131-45-5
Molecular Formula:C₁₂H₂₂ClNO₃
Molecular Weight:263.765
Hs Code.:
Mol file:1312131-45-5.mol

Synonyms:tert-butyl 4-(chloromethyl)-4-(hydroxymethyl)piperidine-1-carboxylate;4-Chloromethyl-4-Hydroxymethyl-Piperidine-1-Carboxylic Acid Tert-Butyl Ester

Suppliers and Price of tert-butyl 4-(chloromethyl)-4-(hydroxymethyl)piperidine-1-carboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
4-Chloromethyl-4-hydroxymethyl-piperidine-1-carboxylicAcidtert-ButylEster
100mg
$ 285.00

Crysdot
tert-Butyl4-(chloromethyl)-4-(hydroxymethyl)piperidine-1-carboxylate 95+%
1g
$ 546.00

Chemenu
tert-Butyl4-(chloromethyl)-4-(hydroxymethyl)piperidine-1-carboxylate 95%
1g
$ 515.00

Alichem
4-Chloromethyl-4-hydroxymethyl-piperidine-1-carboxylicacidtert-butylester
1g
$ 638.00

Total 6 raw suppliers

Chemical Property of tert-butyl 4-(chloromethyl)-4-(hydroxymethyl)piperidine-1-carboxylate

Chemical Property:

PSA：49.77000
LogP:2.17270

Purity/Quality:

98% ^*data from raw suppliers

4-Chloromethyl-4-hydroxymethyl-piperidine-1-carboxylicAcidtert-ButylEster ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of tert-butyl 4-(chloromethyl)-4-(hydroxymethyl)piperidine-1-carboxylate

There total 2 articles about tert-butyl 4-(chloromethyl)-4-(hydroxymethyl)piperidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 1314319-01-1
1-tert-butyl 4-methyl 4-(chloromethyl)piperidine-1,4-dicarboxylate

: 1312131-45-5
tert-butyl 4-(chloromethyl)-4-(hydroxymethyl)piperidine-1-carboxylate

Guidance literature:: With lithium aluminium tetrahydride; In tetrahydrofuran; at 0 ℃; for 0.5h;
DOI:10.1016/j.bmcl.2013.07.044

Reference yield:

: 124443-68-1
1-tert-Butyl 4-methyl piperidine-1,4-dicarboxylate

: 1312131-45-5
tert-butyl 4-(chloromethyl)-4-(hydroxymethyl)piperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: lithium diisopropyl amide

2: lithium aluminium tetrahydride

With lithium aluminium tetrahydride; lithium diisopropyl amide;
DOI:10.1016/j.tetlet.2011.05.027

Reference yield:

: 1312131-45-5
tert-butyl 4-(chloromethyl)-4-(hydroxymethyl)piperidine-1-carboxylate

: 1334782-54-5
2-(4-methoxyphenyl)-1-{2-[(1R)-5-(pyrimidin-2-yl)-2,3-dihydro-1H-inden-1-yl]-2,7-diazaspiro[3.5]non-7-yl}ethanone

Guidance literature:: Multi-step reaction with 5 steps

1.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 0.45 h / -78 °C

1.2: -78 - 20 °C

1.3: 20 °C

2.1: methanol / 16 h / 50 °C

2.2: 26 h / 20 - 60 °C / Inert atmosphere

3.1: bis(pinacol)diborane; potassium acetate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane / 5.5 h / 110 °C / Inert atmosphere

3.2: 20.25 h / 110 °C / Inert atmosphere

4.1: hydrogenchloride / 1,4-dioxane / 3 h / 20 °C

5.1: triethylamine; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate / N,N-dimethyl-formamide / 20 h / 20 °C

With hydrogenchloride; oxalyl dichloride; potassium acetate; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; dimethyl sulfoxide; triethylamine; bis(pinacol)diborane; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In 1,4-dioxane; methanol; dichloromethane; N,N-dimethyl-formamide;