11-Deoxy Prednisolone

Base Information

• Chemical Name: 11-Deoxy Prednisolone
• CAS No.: 1807-14-3
• Molecular Formula: C₂₁H₂₈O₄
• Molecular Weight: 344.451
• Mol file: 1807-14-3.mol

Synonyms:11-Deoxy Prednisolone;1,4-Reichstein S;17,21-Dihydroxypregna-1,4-diene-3,20-dione;17α,21-Dihydroxypregna-1,4- diene-3,20-dione;Δ'-Dehydrocortexolone

Chemical Property of 11-Deoxy Prednisolone

Chemical Property:

• PSA: 74.60000
• LogP: 2.58680
• Storage Temp.: Refrigerator
• Solubility.: Chloroform (Slightly, Heated, Sonicated), DMSO (Slightly, Sonicated), Ethanol (S

Purity/Quality:

98%,99%, ^*data from raw suppliers

11-DeoxyPrednisolone ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Prednisolone (P703740) derivative as corticosteroid. Prednisolone (P703740) derivative as a corticosteroid. 11-Deoxy Prednisolone (Prednisolone EP Impurity J) is a Prednisolone (P703740) derivative as a corticosteroid.

Technology Process of 11-Deoxy Prednisolone

There total 20 articles about 11-Deoxy Prednisolone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

Cortexolone (152-58-9) → 17α,21-dihydroxypregna-1,4-diene-3,20-dione (1807-14-3)

Guidance literature:

mit Hilfe von Corinebacterium simplex;

DOI:10.1021/ja01620a079 DOI:10.1016/S0040-4020(01)92709-7

Reference yield:

17α,21-dihydroxypregna-1,4-diene-3,20-dione 17,21-diacetate (71842-04-1) → 17α,21-dihydroxypregna-1,4-diene-3,20-dione (1807-14-3)

Guidance literature:

With potassium hydroxide;

DOI:10.1021/ja01585a031

Reference yield:

17-Hydroxypregnenolone (387-79-1) → 17α,21-dihydroxypregna-1,4-diene-3,20-dione (1807-14-3)

Guidance literature:

Multi-step reaction with 10 steps

1: water

2: CH₂Cl₂; bromine

3: acetone; NaI

5: toluene-4-sulfonic acid

6: aqueous HCl

7: palladium/charcoal / Hydrogenation_.Oxidation mit CrO₃

9: 2,4,6-trimethyl-pyridine; 2,4-dimethyl-pyridine

10: methanol.KOH

With 2,4,6-trimethyl-pyridine; hydrogenchloride; potassium hydroxide; palladium on activated charcoal; 2,4-lutidine; dichloromethane; water; bromine; toluene-4-sulfonic acid; acetone; sodium iodide;

DOI:10.1021/ja01585a031

upstream raw materials:

Cortexolone

17α,21-dihydroxypregna-1,4-diene-3,20-dione 21-acetate

17α,21-dihydroxypregna-1,4-diene-3,20-dione 17,21-diacetate

cortexolone 21-acetate

Downstream raw materials:

11α,17α,21-trihydroxypregna-1,4-diene-3,20-dione

17α,21-dihydroxypregna-1,4-diene-3,20-dione 21-acetate

Refernces

• 1、 Costa Pla. "Microbiological transformation of steroids. 1 Dehydrogenation of 17,21 dihydroxypregn 4 ene 3,20 dione with Glomerella cingulata". . p. 501 - 502. Retrieved 2007/10/13.