2-Bromo-4-ethylaniline

Base Information

• Chemical Name: 2-Bromo-4-ethylaniline
• CAS No.: 38678-86-3
• Molecular Formula: C8H10BrN
• Molecular Weight: 200.078
• European Community (EC) Number: 861-745-2
• Nikkaji Number: J2.613.263K
• Mol file: 38678-86-3.mol

Synonyms:2-Bromo-4-ethylaniline;38678-86-3;2-broMo-4-ethylbenzenaMine;2-Bromo-4-ethylphenylamine;MFCD00672953;SCHEMBL1063295;UNXYMQGCZRBOMI-UHFFFAOYSA-N;AKOS017547755;SB78297;AM806904;AS-55182;SY123282;CS-0190125;EN300-708828;Y10850

Chemical Property of 2-Bromo-4-ethylaniline

Chemical Property:

• PSA: 26.02000
• LogP: 3.17490
• XLogP3: 2.7
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 1
• Exact Mass: 198.99966
• Heavy Atom Count: 10
• Complexity: 105

Purity/Quality:

99% ^*data from raw suppliers

2-Bromo-4-Ethylaniline 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCC1=CC(=C(C=C1)N)Br

Technology Process of 2-Bromo-4-ethylaniline

There total 7 articles about 2-Bromo-4-ethylaniline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

4-aminoethylbenzene (589-16-2) → 2-bromine-4-ethylaniline (38678-86-3)

Guidance literature:

With N-Bromosuccinimide; In N,N-dimethyl-formamide; at 0 ℃; for 0.166667h;

Reference yield: 91.0%

2-amino-1-bromo-5-ethylbenzene hydrochloride → 2-bromine-4-ethylaniline (38678-86-3)

Guidance literature:

With sodium hydroxide; In ethanol; water;

DOI:10.1016/j.ejmech.2012.01.053

Reference yield: 87.2%

N-(2-bromo-4-ethylphenyl)acetamide (90868-93-2) → 2-bromine-4-ethylaniline (38678-86-3)

Guidance literature:

With potassium hydroxide; In ethanol; water; at 80 ℃; for 5h;

DOI:10.1021/acsmedchemlett.1c00613

upstream raw materials:

N-(2-bromo-4-ethylphenyl)acetamide

N-(4-ethylphenyl)acetamide

4-aminoethylbenzene

4-ethylnitrobenzene

Downstream raw materials:

2-bromo-4-ethyl-1-iodobenzene

018TL

C₂₅H₂₁NO₃

methyl 2-(4-(5,11-dihydro-2-ethyl-5-methyl-11-methylene-6-oxodibenz[b,e]azepin-8-yl)phenyl)acetate