tert-butyl 3-(4-(trifluoroMethyl)pyridin-2-yl)azetidine-1-carboxylate

Base Information

Chemical Name:tert-butyl 3-(4-(trifluoroMethyl)pyridin-2-yl)azetidine-1-carboxylate
CAS No.:1161829-68-0
Molecular Formula:C14H17F3N2O2
Molecular Weight:302.29
Hs Code.:
Mol file:1161829-68-0.mol

Synonyms:tert-butyl 3-(4-(trifluoroMethyl)pyridin-2-yl)azetidine-1-carboxylate

Suppliers and Price of tert-butyl 3-(4-(trifluoroMethyl)pyridin-2-yl)azetidine-1-carboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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Total 3 raw suppliers

Chemical Property of tert-butyl 3-(4-(trifluoroMethyl)pyridin-2-yl)azetidine-1-carboxylate

Chemical Property:

Boiling Point:349.1±42.0 °C(Predicted)
PKA:2.81±0.27(Predicted)
PSA：42.43000
Density:1.258±0.06 g/cm3(Predicted)
LogP:3.37260

Purity/Quality:: 98%min ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of tert-butyl 3-(4-(trifluoroMethyl)pyridin-2-yl)azetidine-1-carboxylate

There total 2 articles about tert-butyl 3-(4-(trifluoroMethyl)pyridin-2-yl)azetidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 44.0%

: 3796-24-5
4-trifluoromethylpyridine

: 254454-54-1
tert-butyl-3-iodoazetidine-1-carboxylate

: 1161829-68-0
tert-butyl 3-(4-(trifluoromethyl)pyridin-2-yl)azetidine-1-carboxylate

Guidance literature:: 4-trifluoromethylpyridine; tert-butyl-3-iodoazetidine-1-carboxylate; With dimanganese decacarbonyl; trifluoroacetic acid; In dimethyl sulfoxide; at 20 ℃; for 18h; Sealed tube; Irradiation;

DOI:10.1002/anie.201707958

Reference yield: 37.0%

: 206446-38-0
(1-(tert-butoxycarbonyl)azetidin-3-yl)zinc(II) iodide

: 175205-81-9
2-bromo-4-(trifluoromethyl)pyridine

: 1161829-68-0
tert-butyl 3-(4-(trifluoromethyl)pyridin-2-yl)azetidine-1-carboxylate

Guidance literature:: With iodobenzene; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; trifuran-2-yl-phosphane; In tetrahydrofuran; at 20 - 65 ℃; for 2.16667h;