2-Bromo-4-(trifluoromethyl)pyridine

Base Information

Chemical Name:2-Bromo-4-(trifluoromethyl)pyridine
CAS No.:175205-81-9
Molecular Formula:C6H3BrF3N
Molecular Weight:225.996
Hs Code.:2933399090
European Community (EC) Number:672-057-5
DSSTox Substance ID:DTXSID60381807
Nikkaji Number:J2.072.898A
Wikidata:Q72513476
Mol file:175205-81-9.mol

Synonyms:2-Bromo-4-(trifluoromethyl)pyridine;175205-81-9;2-bromo-4-trifluoromethylpyridine;Pyridine, 2-bromo-4-(trifluoromethyl)-;MFCD00153085;2-bromo-4-trifluoromethyl-pyridine;SCHEMBL136851;2-Bromo-4-trifluormethylpyridine;AMY3071;DTXSID60381807;MPHQSLJGFDHFKK-UHFFFAOYSA-N;BBL103091;STL556901;AKOS005145687;AB04062;CS-W002441;PS-6522;AC-29115;SY007961;2-Bromo-4-(trifluoromethyl)pyridine, 97%;A3884;B5510;FT-0643691;EN300-74588

Suppliers and Price of 2-Bromo-4-(trifluoromethyl)pyridine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
2-Bromo-4-(trifluoromethyl)pyridine
1g
$ 95.00

TCI Chemical
2-Bromo-4-(trifluoromethyl)pyridine
1G
$ 93.00

TCI Chemical
2-Bromo-4-(trifluoromethyl)pyridine
5G
$ 322.00

SynQuest Laboratories
2-Bromo-4-(trifluoromethyl)pyridine
25 g
$ 325.00

SynQuest Laboratories
2-Bromo-4-(trifluoromethyl)pyridine
1 g
$ 45.00

SynQuest Laboratories
2-Bromo-4-(trifluoromethyl)pyridine
250 mg
$ 20.00

SynQuest Laboratories
2-Bromo-4-(trifluoromethyl)pyridine
5 g
$ 125.00

Sigma-Aldrich
2-Bromo-4-(trifluoromethyl)pyridine 97%
1g
$ 86.80

Sigma-Aldrich
2-Bromo-4-(trifluoromethyl)pyridine 97%
500mg
$ 53.90

Oakwood
2-Bromo-4-(trifluoromethyl)pyridine
5g
$ 48.00

Total 78 raw suppliers

Chemical Property of 2-Bromo-4-(trifluoromethyl)pyridine

Chemical Property:

Vapor Pressure:0.622mmHg at 25°C
Melting Point:-21--20 °C
Refractive Index:n20/D 1.478
Boiling Point:195.9 °C at 760 mmHg
PKA:-1.57±0.10(Predicted)
Flash Point:72.3 °C
PSA：12.89000
Density:1.707 g/cm³
LogP:2.86290
Storage Temp.:Keep in dark place,Sealed in dry,Room Temperature
XLogP3:2.8
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:0
Exact Mass:224.94010
Heavy Atom Count:11
Complexity:136

Purity/Quality:

99% ^*data from raw suppliers

2-Bromo-4-(trifluoromethyl)pyridine ^*data from reagent suppliers

Safty Information:

Pictogram(s): T, Xi
Hazard Codes:T,Xi
Statements: 25-36/37/38-37/38-36
Safety Statements: 26-36/37-45-37

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=CN=C(C=C1C(F)(F)F)Br
Uses 2-Bromo-4-(trifluoromethyl)pyridine in used in the preparation of pyrazolopyridines as kinase LRRK2 inhibitors for treating and preventing cancer and neurodegenerative diseases. Regioselective deprotonation at C-3 with LDA followed by trapping with carbon dioxide provides the correspondin nicotinic acid.

Technology Process of 2-Bromo-4-(trifluoromethyl)pyridine

There total 2 articles about 2-Bromo-4-(trifluoromethyl)pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: (E)-5-ethoxy-3-hydroxy-3-(trifluoromethyl)pent-4-enenitrile

: 175205-81-9
2-bromo-4-(trifluoromethyl)pyridine

Guidance literature:: With hydrogen bromide; In dichloromethane; at 20 ℃; Product distribution / selectivity;

Reference yield: 65.0%

: 81565-18-6
2-chloro-4-trifluoromethyl pyridine

: 175205-81-9
2-bromo-4-(trifluoromethyl)pyridine

Guidance literature:: With trimethylsilyl bromide; In various solvent(s); for 20h; Heating;
DOI:10.1002/ejoc.200390215

Reference yield: 97.5%

: 68572-87-2
9-phenanthrenylboronic acid

: 175205-81-9
2-bromo-4-(trifluoromethyl)pyridine

: 2-(phenanthren-9-yl)-4-(trifluoromethyl)pyridine

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; In tetrahydrofuran; water; at 80 ℃; for 24h; Inert atmosphere;
DOI:10.1080/15421406.2016.1200941