2-[4-(4-benzhydrylpiperazin-1-yl)phenyl]ethyl methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate

Base Information

• Chemical Name: 2-[4-(4-benzhydrylpiperazin-1-yl)phenyl]ethyl methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
• CAS No.: 134054-36-7
• Molecular Formula: C₄₁H₄₂N₄O₆
• Molecular Weight: 686.808
• Mol file: 134054-36-7.mol

Synonyms:2-[4-(4-benzhydrylpiperazin-1-yl)phenyl]ethyl methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate

Chemical Property of 2-[4-(4-benzhydrylpiperazin-1-yl)phenyl]ethyl methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-[4-(4-benzhydrylpiperazin-1-yl)phenyl]ethyl methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate

There total 6 articles about 2-[4-(4-benzhydrylpiperazin-1-yl)phenyl]ethyl methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 48.0%

2-<4-(4-benzhydryl-1-piperazinyl)phenyl>ethyl acetoacetate (116308-41-9) + methyl 3-aminocrotonate (21731-17-9) → 4-(4-benzhydrylpiperazino)phenetyl methyl 1,4-dihydro-2-6-dimethyl-4-(3-nitrophenyl)-3,5-pyridine (116308-55-5,134054-36-7)

Guidance literature:

In 3-nitro-benzaldehyde; isopropyl alcohol;

Reference yield: 48.0%

→ 4-(4-benzhydrylpiperazino)phenetyl methyl 1,4-dihydro-2-6-dimethyl-4-(3-nitrophenyl)-3,5-pyridine (116308-55-5,134054-36-7)

Guidance literature:

Reference yield:

(R)-5-(methoxycarbonyl)-2,6-dimethyl-4-(m-nitrophenyl)-1,4-dihydropyridine-3-carboxylic acid (76093-33-9) → (4S)-(+)-2-<4-(4-Benzhydryl-1-piperazinyl)phenyl>ethyl methyl 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylate (134028-04-9,116308-55-5,134054-36-7)

Guidance literature:

Multi-step reaction with 2 steps

1: SOCl₂ / CH₂Cl₂; dimethylformamide / 2.5 h / 5 - 9 °C

2: CH₂Cl₂; dimethylformamide / 16 h / 5 °C

With thionyl chloride; In dichloromethane; N,N-dimethyl-formamide;

DOI:10.1248/cpb.39.108

upstream raw materials:

2-<4-(4-benzhydryl-1-piperazinyl)phenyl>ethyl alcohol

methyl (R)-5-chlorocarbonyl-2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3-carboxylate

methyl (R)-5-chlorocarbonyl-2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3-carboxylate

(R)-5-(methoxycarbonyl)-2,6-dimethyl-4-(m-nitrophenyl)-1,4-dihydropyridine-3-carboxylic acid