3-BROMO-4-FLUOROBENZOHYDRAZIDE

Base Information

• Chemical Name: 3-BROMO-4-FLUOROBENZOHYDRAZIDE
• CAS No.: 929884-90-2
• Molecular Formula: C7H6BrFN2O
• Molecular Weight: 233.04
• Mol file: 929884-90-2.mol

Synonyms:3-BROMO-4-FLUOROBENZOHYDRAZIDE

Chemical Property of 3-BROMO-4-FLUOROBENZOHYDRAZIDE

Chemical Property:

• PSA: 58.61000
• LogP: 2.46680

Purity/Quality:

99% ^*data from raw suppliers

3-Bromo-4-fluorobenzohydrazide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-BROMO-4-FLUOROBENZOHYDRAZIDE

There total 3 articles about 3-BROMO-4-FLUOROBENZOHYDRAZIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

methyl 3-bromo-4-fluorobenzoate (82702-31-6) → 3-bromo-4-fluorobenzohydrazide (929884-90-2)

Guidance literature:

With hydrazine hydrate; In ethanol; for 6h; Reflux;

DOI:10.3109/14756366.2011.606543

Reference yield:

3-bromo-4-fluorobenzoic acid (1007-16-5) → 3-bromo-4-fluorobenzohydrazide (929884-90-2)

Guidance literature:

3-bromo-4-fluorobenzoic acid; With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In water; acetonitrile; for 2h;

With hydrazine; In water; acetonitrile; at 0 ℃; for 1h;

Reference yield:

4-Fluorobenzoic acid (456-22-4) → 3-bromo-4-fluorobenzohydrazide (929884-90-2)

Guidance literature:

Multi-step reaction with 3 steps

1: potassium bromate; sulfuric acid / water / 5 h / 80 - 100 °C

2: sulfuric acid / 4 h / Reflux

3: hydrazine hydrate / ethanol / 6 h / Reflux

With potassium bromate; sulfuric acid; hydrazine hydrate; In ethanol; water;

DOI:10.3109/14756366.2011.606543

upstream raw materials:

3-bromo-4-fluorobenzoic acid

4-Fluorobenzoic acid

methyl 3-bromo-4-fluorobenzoate

Downstream raw materials:

2-(3-bromo-4-fluorophenyl)-5-phenyl-1,3,4-oxadiazole

2-(3-bromo-4-fluorophenyl)-5-(4-chlorophenyl)-1,3,4-oxadiazole

2-(3-bromo-4-fluorophenyl)-5-(4-fluorophenyl)-1,3,4-oxadiazole

2-(3-bromo-4-fluorophenyl)-5-(4-methylphenyl)-1,3,4-oxadiazole

Refernces

• 1、 -. "2-Heteroaryl-pyrazolo-[4,3-e]-1,2,4-triazolo-[1,5-c]-pyrimidine adenosine A2a receptor antagonists". Page/Page column 23. . Retrieved 2008/06/13.