1007-16-5

Basic information

• Product Name: 3-Bromo-4-fluorobenzoic acid
• Synonyms: BUTTPARK 20\01-58;3-BROMO-4-FLUOROBENZOIC ACID;RARECHEM AL BO 0604;3-Bromo-4-fluorobenzoic acid 98%;3-Bromo-4-fluorobenzoicacid98%;3-BROMO-4-FIUOROBENZOIC ACID;Bromo-4-fluoro-benzoic acid
• CAS NO: 1007-16-5
• Molecular Formula: C₇H₄BrFO₂
• Molecular Weight: 219.01
• EINECS: 213-751-6
• Product Categories: Fluorin-contained Benzoic acid series;blocks;Bromides;Carboxes;FluoroCompounds;Aromatic Carboxylic Acids, Amides, Anilides, Anhydrides & Salts;Benzoic acid;Fluorobenzene;Miscellaneous;Acids & Esters;Bromine Compounds;Fluorine Compounds;C7;Carbonyl Compounds;Carboxylic Acids;Benzoic acid series;intermediate
• Mol File: 1007-16-5.mol
• Article Data: 13

Chemical Properties

• Melting Point: 138-140 °C(lit.)
• Boiling Point: 306.6 °C at 760 mmHg
• Flash Point: 139.2 °C
• Appearance: White to slightly beige/Crystalline Powder
• Density: 1.789 g/cm³
• Vapor Pressure: 0.000333mmHg at 25°C
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 3.75±0.10(Predicted)
• CAS DataBase Reference: 3-Bromo-4-fluorobenzoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Bromo-4-fluorobenzoic acid(1007-16-5)
• EPA Substance Registry System: 3-Bromo-4-fluorobenzoic acid(1007-16-5)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-37/39-36
• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 1007-16-5(Hazardous Substances Data)

Usage

Chemical Properties

white to light yellow crystal powder

Uses

3-Bromo-4-fluorobenzoic acid may be used in chemical synthesis.

InChI:InChI=1/C7H4BrFO2/c8-5-3-4(7(10)11)1-2-6(5)9/h1-3H,(H,10,11)/p-1

Upstream product

• 452-62-0 3-bromo-4-fluorotoluene 
• 456-22-4 4-Fluorobenzoic acid 
• 77771-02-9 3-bromo-4-fluorobenzaldehyde 
• 1007-15-4 4-fluoro-3-bromoacetophenone 
• 765916-94-7 (3-bromo-4-fluorophenyl)(oxo)acetaldehyde 
• 79630-23-2 3-bromo-4-fluorobenzonitrile 
• 13194-71-3 2-bromo-4-methyl-aniline; hydrochloride 
• 352-32-9 p-fluorotoluene 

Downstream Products

• 672-75-3 3-bromo-4-fluorobenzoyl chloride 
• 656-64-4 3-bromo-4-fluoroaniline 
• 23233-33-2 ethyl 3-bromo-4-fluorobenzoate 
• 82702-31-6 methyl 3-bromo-4-fluorobenzoate 
• 1378847-99-4 4-fluoro-3-propionylbenzoic acid 
• 77771-03-0 3-bromo-4-fluoro-benzyl alcohol 
• 668268-20-0 methyl 2-{[4-(benzylthio)-3-bromobenzoyl]amino}-5-chlorobenzoate 
• 375368-94-8 tert-butyl 3-bromo-4-fluorobenzoate 
• 1380305-68-9 methyl 3-bromo-4-fluoro-5-methylbenzoate 
• 1380305-66-7 methyl 3-bromo-4-fluoro-2-methylbenzoate 
• 1072-85-1 o-fluorobromobenzene 
• 1399743-59-9 C₂₉H₃₂BrNO₂ 
• 1195765-71-9 N-{5-[5-(2-Amino-4-pyrimidinyl)-2-(1-methylethyl)-1,3-thiazol-4-yl]-2-fluorophenyl}-3-fluorobenzenesulfonamide 
• 369-26-6 methyl 3-amino-4-fluorobenzoate 

Relevant articles and documents

An efficient one pot method for synthesis of carboxylic acids from nitriles using recyclable ionic liquid [bmim]HSO4 Dedicated to my mentor Professor (Mrs.) Krishna Misra on her 76th birthday

Environmentally benign ionic liquid [bmim]HSO4 was found suitable for conversion of nitriles into carboxylic acids under mild conditions with excellent purity.

Halogens halt aromatic group migration in Baeyer-Villiger oxidation

Oxidation of a dihalogenated benzaldehyde under Baeyer-Villiger conditions led to the aromatic carboxylic acid as opposed to the desired phenol. Fluorine was located at the para-position of the benzaldehyde, halting migration of the aryl group and thus resulting in the carboxylic acid product.

GLUCOSE-SENSITIVE ALBUMIN-BINDING DERIVATIVES

This invention relates to glucose-sensitive albumin-binding diboron conjugates. More particularly the invention provides novel diboron compounds, and in particular diboronate or diboroxole compounds, useful as intermediate compounds for the synthesis of diboron conjugates. The diboron compounds are characterized by formula (I), which is: R1-X-R2, and wherein "X" is a mono- to multiatomic linker and where R1 and R2, which may be identical or different, each represents a group of Formula (lla) or (IIb) Also described are diboron conjugates represented by the general Formula (I'), which is: R1'-X'-R2', in which either the moeities R1' or R2' or X' carry a drug that is covalently attached to the diboron compound.

A Metal-Free Approach to Carboxylic Acids by Oxidation of Alkyl, Aryl, or Heteroaryl Alkyl Ketones or Arylalkynes

The metal-free oxidation of dialkyl, alkyl aryl, or alkyl heteroaryl ketones or arylalkynes to the corresponding carboxylic acids is achieved using an oxidative mixture of Oxone and trifluoroacetic acid. This green method is a simple and mild protocol to obtain carboxylic derivatives in excellent yields.