7-Aza-2-oxindole-6-carboxylic acid Methyl este

Base Information

• Chemical Name: 7-Aza-2-oxindole-6-carboxylic acid Methyl este
• CAS No.: 1227268-70-3
• Molecular Formula: C₉H₈N₂O₃
• Molecular Weight: 192.174
• Mol file: 1227268-70-3.mol

Synonyms:7-Aza-2-oxindole-6-carboxylic acid Methyl este;7-Aza-2-oxindole-6-carboxylic acid methyl ester

Chemical Property of 7-Aza-2-oxindole-6-carboxylic acid Methyl este

Chemical Property:

• PSA: 71.78000
• LogP: 0.44790
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

97% ^*data from raw suppliers

Methyl2-Oxo-2,3-dihydro-1H-pyrrolo[2,3-b]pyridine-6-carboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 7-Aza-2-oxindole-6-carboxylic acid Methyl este

There total 3 articles about 7-Aza-2-oxindole-6-carboxylic acid Methyl este which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

methyl 3,3-dibromo-2-oxo-7-azaindole-6-carboxylate → methyl 2-oxo-2,3-dihydro-1H-pyrrolo[2,3-b]pyridine-6-carboxylate (1227268-70-3)

Guidance literature:

methyl 3,3-dibromo-2-oxo-7-azaindole-6-carboxylate; With ammonium chloride; In tetrahydrofuran; water; at 40 ℃; for 0.5h;

With zinc; In tetrahydrofuran; water; at 20 ℃; for 0.5h;

Reference yield:

1H-pyrrolo[2,3-b]pyridine-6-carbonitrile (189882-33-5) → methyl 2-oxo-2,3-dihydro-1H-pyrrolo[2,3-b]pyridine-6-carboxylate (1227268-70-3)

Guidance literature:

Multi-step reaction with 4 steps

1.1: sodium hydroxide / ethanol / 80 °C

2.1: sulfuric acid / 70 °C

3.1: pyridinium hydrobromide perbromide / tert-butyl alcohol / 2 h / 40 °C

4.1: ammonium chloride / tetrahydrofuran; water / 0.5 h / 40 °C

4.2: 0.5 h / 20 °C

With pyridinium hydrobromide perbromide; sulfuric acid; ammonium chloride; sodium hydroxide; In tetrahydrofuran; ethanol; water; tert-butyl alcohol;

Reference yield:

1H-pyrrolo[2,3-b]pyridine-6-carboxylic acid (898746-35-5) → methyl 2-oxo-2,3-dihydro-1H-pyrrolo[2,3-b]pyridine-6-carboxylate (1227268-70-3)

Guidance literature:

Multi-step reaction with 3 steps

1.1: sulfuric acid / 70 °C

2.1: pyridinium hydrobromide perbromide / tert-butyl alcohol / 2 h / 40 °C

3.1: ammonium chloride / tetrahydrofuran; water / 0.5 h / 40 °C

3.2: 0.5 h / 20 °C

With pyridinium hydrobromide perbromide; sulfuric acid; ammonium chloride; In tetrahydrofuran; water; tert-butyl alcohol;

upstream raw materials:

1H-pyrrolo[2,3-b]pyridine-6-carbonitrile

1H-pyrrolo[2,3-b]pyridine-6-carboxylic acid

Downstream raw materials:

(E)-methyl 1-acetyl-3-(ethoxy(phenyl)methylene)-2-oxo-2,3-dihydro-1H-pyrrolo[2,3-b]pyridine-6-carboxylate

(Z)-methyl 3-(((4-(N-methyl-2-(4-methylpiperazin-1-yl)acetamido)phenyl)amino)(phenyl)methylene)-2-oxo-2,3-dihydro-1H-pyrrolo[2,3-b]pyridine-6-carboxylate

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