1H-PYRROLO[2,3-B]PYRIDINE-6-CARBOXYLIC ACID

Base Information

• Chemical Name: 1H-PYRROLO[2,3-B]PYRIDINE-6-CARBOXYLIC ACID
• CAS No.: 898746-35-5
• Molecular Formula: C8H6 N2 O2
• Molecular Weight: 162.15
• Hs Code.: 2933998090
• Mol file: 898746-35-5.mol

Synonyms:7-AZAINDOLE-6-CARBOXYLIC ACID;1H-PYRROLO[2,3-B]PYRIDINE-6-CARBOXYLIC ACID

Chemical Property of 1H-PYRROLO[2,3-B]PYRIDINE-6-CARBOXYLIC ACID

Chemical Property:

• PKA: 1.44±0.30(Predicted)
• Density: 1.506±0.06 g/cm3(Predicted)
• Storage Temp.: 2-8°C

Purity/Quality:

99%, ^*data from raw suppliers

1H-Pyrrolo[2,3-b]pyridine-6-carboxylicAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1H-PYRROLO[2,3-B]PYRIDINE-6-CARBOXYLIC ACID

There total 3 articles about 1H-PYRROLO[2,3-B]PYRIDINE-6-CARBOXYLIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

1H-pyrrolo[2,3-b]pyridine-6-carbonitrile (189882-33-5) → 1H-pyrrolo[2,3-b]pyridine-6-carboxylic acid (898746-35-5)

Guidance literature:

With sodium hydroxide; In ethanol; at 90 ℃; for 18h;

Reference yield:

ethyl 1H-pyrrolo[2,3-b]pyridine-6-carboxylate → 1H-pyrrolo[2,3-b]pyridine-6-carboxylic acid (898746-35-5)

Guidance literature:

With sodium hydroxide; In 1,4-dioxane; at 80 ℃; for 1h;

Reference yield:

6-Bromo-1H-pyrrolo<2,3-b>pyridine (143468-13-7) → 1H-pyrrolo[2,3-b]pyridine-6-carboxylic acid (898746-35-5)

Guidance literature:

Multi-step reaction with 2 steps

1.1: zinc / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / N,N-dimethyl-formamide / 4 h / 140 °C / Inert atmosphere

2.1: sodium hydroxide; water / 6 h / 100 °C

2.2: pH 6 - 7

With water; sodium hydroxide; zinc; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In N,N-dimethyl-formamide;

upstream raw materials:

6-Bromo-1H-pyrrolo<2,3-b>pyridine

1H-pyrrolo[2,3-b]pyridine-6-carbonitrile

Downstream raw materials:

1H-pyrrolo[2,3-b]pyridin-6-ylmethanol

methyl 2-oxo-2,3-dihydro-1H-pyrrolo[2,3-b]pyridine-6-carboxylate

methyl 3-iodo-1H-pyrrolo[2,3-b]pyridine-6-carboxylate

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