2-(N-tert-butoxycarbonyl-3-hydroxyazetidin-3-yl)acetic acid

Base Information

• Chemical Name: 2-(N-tert-butoxycarbonyl-3-hydroxyazetidin-3-yl)acetic acid
• CAS No.: 1154760-03-8
• Molecular Formula: C10H17NO5
• Molecular Weight: 231.24568
• Mol file: 1154760-03-8.mol

Synonyms:2-(N-tert-butoxycarbonyl-3-hydroxyazetidin-3-yl)acetic acid;2-(1-(tert-butoxycarbonyl)-3-hydroxyazetidin-3-yl)acetic acid

Chemical Property of 2-(N-tert-butoxycarbonyl-3-hydroxyazetidin-3-yl)acetic acid

Chemical Property:

• PSA: 87.07000
• LogP: 0.38080

Purity/Quality:

97% ^*data from raw suppliers

2-(1-(tert-Butoxycarbonyl)-3-hydroxyazetidin-3-yl)aceticAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-(N-tert-butoxycarbonyl-3-hydroxyazetidin-3-yl)acetic acid

There total 5 articles about 2-(N-tert-butoxycarbonyl-3-hydroxyazetidin-3-yl)acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

di-tert-butyl dicarbonate (24424-99-5) + tert-butyl 3-(2-(tert-butoxy)-2-oxoethyl)-3-hydroxyazetidine-1-carboxylate (1154760-02-7) → 2-(1-(tert-butoxycarbonyl)-3-hydroxyazetidin-3-yl)acetic acid (1154760-03-8)

Guidance literature:

tert-butyl 3-(2-(tert-butoxy)-2-oxoethyl)-3-hydroxyazetidine-1-carboxylate; With hydrogenchloride; water; In 1,4-dioxane; at 70 ℃; for 1h;

di-tert-butyl dicarbonate; With water; sodium hydroxide; In 1,4-dioxane; at 0 - 20 ℃; for 2h;

With hydrogenchloride; In chloroform; water; isopropyl alcohol; at 0 ℃; pH=3;

Reference yield: 88.7%

tert-butyl 3-(2-ethoxy-2-oxoethyl)-3-hydroxyazetidine-1-carboxylatetert-butyl 3-(2-ethoxy-2-oxoethyl)-3-hydroxyazetidine-1-carboxylate → 2-(1-(tert-butoxycarbonyl)-3-hydroxyazetidin-3-yl)acetic acid (1154760-03-8)

Guidance literature:

With lithium hydroxide; In tetrahydrofuran; water; at 0 - 20 ℃; for 2h;

Reference yield:

di-tert-butyl dicarbonate (24424-99-5) + C5H9NO3*ClH → 2-(1-(tert-butoxycarbonyl)-3-hydroxyazetidin-3-yl)acetic acid (1154760-03-8)

Guidance literature:

di-tert-butyl dicarbonate; C₅H₉NO₃*ClH; With sodium hydroxide; In 1,4-dioxane; water; at 0 - 20 ℃; for 2h;

With hydrogenchloride; In chloroform; water; isopropyl alcohol; at 0 ℃; pH=3;

upstream raw materials:

di-tert-butyl dicarbonate

tert-butyl 3-(2-(tert-butoxy)-2-oxoethyl)-3-hydroxyazetidine-1-carboxylate

tert-butyl 3-oxoazetidine-1-carboxylate

Downstream raw materials:

tert-butyl 7-[4-(methoxycarbonyl)phenyl]-6-oxo-5-oxa-2,7-diazaspiro[3.4]octane-2-carboxylate

6-oxo-5-oxa-2,7-diazaspiro[3.4]octane-2-carboxylic acid tert-butyl ester