tert-Butyl 6-oxo-5-oxa-2,7-diazaspiro[3.4]octane-2-carboxylate

Base Information

• Chemical Name: tert-Butyl 6-oxo-5-oxa-2,7-diazaspiro[3.4]octane-2-carboxylate
• CAS No.: 1799438-98-4
• Molecular Formula: C10H16N2O4
• Molecular Weight: 228.24
• Mol file: 1799438-98-4.mol

Synonyms:tert-Butyl 6-oxo-5-oxa-2,7-diazaspiro[3.4]octane-2-carboxylate

Chemical Property of tert-Butyl 6-oxo-5-oxa-2,7-diazaspiro[3.4]octane-2-carboxylate

Chemical Property:

• PSA: 67.87000
• LogP: 0.98240

Purity/Quality:

97% ^*data from raw suppliers

tert-Butyl6-Oxo-5-oxa-2,7-diazaspiro[3.4]octane-2-carboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of tert-Butyl 6-oxo-5-oxa-2,7-diazaspiro[3.4]octane-2-carboxylate

There total 7 articles about tert-Butyl 6-oxo-5-oxa-2,7-diazaspiro[3.4]octane-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 8.0%

3-(aminomethyl)-3-hydroxyazetidin-1-carboxylic acid tert-butyl ester (1008526-71-3) + 1,1'-carbonyldiimidazole (530-62-1) → 6-oxo-5-oxa-2,7-diazaspiro[3.4]octane-2-carboxylic acid tert-butyl ester (1799438-98-4)

Guidance literature:

With triethylamine; In tetrahydrofuran;

DOI:10.1021/acscombsci.6b00050

Reference yield:

2-(1-(tert-butoxycarbonyl)-3-hydroxyazetidin-3-yl)acetic acid (1154760-03-8) → 6-oxo-5-oxa-2,7-diazaspiro[3.4]octane-2-carboxylic acid tert-butyl ester (1799438-98-4)

Guidance literature:

With diphenyl phosphoryl azide; triethylamine; In toluene; at 120 ℃; for 16h;

Reference yield:

3-(aminomethyl)-3-hydroxyazetidin-1-carboxylic acid tert-butyl ester (1008526-71-3) + bis(trichloromethyl) carbonate (32315-10-9) → 6-oxo-5-oxa-2,7-diazaspiro[3.4]octane-2-carboxylic acid tert-butyl ester (1799438-98-4)

Guidance literature:

With triethylamine; In dichloromethane; at 20 ℃; for 3h;

upstream raw materials:

tert-butyl 3-oxoazetidine-1-carboxylate

2-(1-(tert-butoxycarbonyl)-3-hydroxyazetidin-3-yl)acetic acid

3-(aminomethyl)-3-hydroxyazetidin-1-carboxylic acid tert-butyl ester

1,1'-carbonyldiimidazole

Downstream raw materials:

5-oxa-2,7-diazaspiro[3.4]octan-6-one