2,2-Difluoro-2-(4-Methoxyphenyl)ethanol

Base Information

• Chemical Name: 2,2-Difluoro-2-(4-Methoxyphenyl)ethanol
• CAS No.: 762292-75-1
• Molecular Formula: C9H10F2O2
• Molecular Weight: 188.174
• Mol file: 762292-75-1.mol

Synonyms:2,2-Difluoro-2-(4-Methoxyphenyl)ethanol;beta,beta-Difluoro-4-methoxybenzeneethanol

Chemical Property of 2,2-Difluoro-2-(4-Methoxyphenyl)ethanol

Chemical Property:

• PSA: 29.46000
• LogP: 1.77930

Purity/Quality:

97% ^*data from raw suppliers

2,2-Difluoro-2-(4-methoxyphenyl)ethanol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2,2-Difluoro-2-(4-Methoxyphenyl)ethanol

There total 8 articles about 2,2-Difluoro-2-(4-Methoxyphenyl)ethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

2,2-difluoro-2-(4-methoxyphenyl)ethyl acetate (762292-73-9) → 2,2-difluoro-2-(4-methoxyphenyl)ethanol (762292-75-1)

Guidance literature:

With sodium hydroxide; In ethanol; at 25 ℃;

DOI:10.1016/j.tet.2004.06.086

Reference yield: 90.0%

4-Methoxyphenylacetaldehyde (5703-26-4) → 2,2-difluoro-2-(4-methoxyphenyl)ethanol (762292-75-1)

Guidance literature:

4-Methoxyphenylacetaldehyde; With L-proline; In N,N-dimethyl acetamide; at 20 ℃; for 0.5h;

With N-fluorobis(benzenesulfon)imide; In N,N-dimethyl acetamide; at 20 ℃; for 4h;

Reference yield: 79.0%

2,2-difluoro-2-(4-methoxyphenyl)acetic acid ethyl ester (112545-98-9) → 2,2-difluoro-2-(4-methoxyphenyl)ethanol (762292-75-1)

Guidance literature:

With sodium tetrahydroborate; In methanol; at 0 ℃; for 1h; Inert atmosphere;

DOI:10.1002/adsc.201701581

upstream raw materials:

2,2-difluoro-2-(4-methoxyphenyl)ethyl acetate

2-Bromo-4'-methoxyacetophenone

1-(2-bromo-1,1-difluoroethyl)-4-methoxybenzene

4-Methoxyphenylacetaldehyde

Downstream raw materials:

2,2-difluoro-2-(4-methoxyphenyl)acetaldehyde

ethyl 3,3-difluoro-2-oxo-3-(4-methoxyphenyl)propionate

3,3-difluoro-2-hydroxy-3-(4-methoxyphenyl)propionitrile

3,3-difluoro-2-oxo-3-(4-methoxyphenyl)propionic acid