4-Methoxyphenylacetaldehyde

Base Information

• Chemical Name: 4-Methoxyphenylacetaldehyde
• CAS No.: 5703-26-4
• Molecular Formula: C9H10O2
• Molecular Weight: 150.177
• Hs Code.: 2912499000
• European Community (EC) Number: 227-191-5
• DSSTox Substance ID: DTXSID30205642
• Nikkaji Number: J225.107H
• Wikidata: Q72517456
• Mol file: 5703-26-4.mol

Synonyms:2-(4-methoxyphenyl)acetaldehyde;4-Methoxyphenylacetaldehyde;5703-26-4;(4-methoxyphenyl)acetaldehyde;BENZENEACETALDEHYDE, 4-METHOXY-;(4-Methoxy-phenyl)-acetaldehyde;p-methoxyphenylacetaldehyde;MFCD02261769;EINECS 227-191-5;(4-Methoxyphenyl)ethanal;4-Methoxybenzeneacetaldehyde;4-methoxyphenyl acetaldehyde;SCHEMBL190915;2-(4-methoxy-phenyl)-ethanone;Acetaldehyde, (p-methoxyphenyl)-;AMY4033;DTXSID30205642;2-(4-methoxyphenyl)-acetaldehyde;AKOS004120674;AB11810;CS-W005835;AC-25619;DS-13285;SY025623;FT-0650756;EN300-243514;F11615;A831287;J-515671;F8883-7622;Z993017620

Chemical Property of 4-Methoxyphenylacetaldehyde

Chemical Property:

• Appearance/Colour: Pale yellow clear liquid
• Vapor Pressure: 0.0162mmHg at 25°C
• Melting Point: 0 °C
• Refractive Index: 1.506
• Boiling Point: 255.5 °C at 760 mmHg
• Flash Point: 108.5 °C
• PSA: 26.30000
• Density: 1.045 g/cm³
• LogP: 1.43660
• Storage Temp.: Inert atmosphere,Store in freezer, under -20°C
• Solubility.: Chloroform (Sparingly)
• XLogP3: 1.4
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 3
• Exact Mass: 150.068079557
• Heavy Atom Count: 11
• Complexity: 115

Purity/Quality:

98%,99%, ^*data from raw suppliers

2-(4-Methoxyphenyl)acetaldehyde ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=CC=C(C=C1)CC=O

Technology Process of 4-Methoxyphenylacetaldehyde

There total 102 articles about 4-Methoxyphenylacetaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

2-(4-Methoxyphenyl)ethanol (702-23-8) → 4-Methoxyphenylacetaldehyde (5703-26-4)

Guidance literature:

With Dess-Martin periodane; In dichloromethane; at 0 - 20 ℃; for 1h;

Reference yield: 96.0%

2-(4-methoxyphenyl)oxirane (6388-72-3) → 4-Methoxyphenylacetaldehyde (5703-26-4)

Guidance literature:

With sodium tetrahydroborate; In benzene; at 45 ℃; for 2.5h;

Reference yield: 93.0%

S-ethyl 2-(4-methoxyphenyl)ethanethioate → 4-Methoxyphenylacetaldehyde (5703-26-4)

Guidance literature:

With triethylsilane; palladium on activated charcoal; In tetrahydrofuran; at 20 ℃; for 2h;

DOI:10.1016/j.tetlet.2004.02.130

upstream raw materials:

4-Methoxystyrene

Estragole

(4-methoxy-styryl)-carbamic acid methyl ester

4-(3-phenylallyl)anisole

Downstream raw materials:

(2-cyclohex-1-enyl-ethyl)-(4-methoxy-styryl)-methyl-amine

1-(4-methoxy-benzyl)-2,3,4,9-tetrahydro-1H-β-carboline

N,O-dimethyl-tyrosine nitrile

4-Methoxyphenylacetic acid

Refernces

• 1、 Yang, Gao-Feng,Li, Guang-Xun,Huang, Jin,Fu, Ding-Qiang,Nie, Xiao-Kang,Cui, Xin,Zhao, Jin-Zhong,Tang, Zhuo. "Regioselective, Diastereoselective, and Enantioselective One-Pot Tandem Reaction Based on an in Situ Formed Reductant: Preparation of 2,3-Disubstituted 1,5-Benzodiazepine". . p. 5110 - 5119. Retrieved 2021/04/12.
• 2、 Li, Jie,Li, Ruoling,Yang, Wen,Zhao, Pei,Zhao, Wanxiang. "Rhodium-Catalyzed β-Dehydroborylation of Silyl Enol Ethers: Access to Highly Functionalized Enolates". supporting information. p. 9580 - 9585. Retrieved 2021/12/14.